Gastric adenocarcinoma of fundic gland type with signet-ring cell carcinoma component: A case report and review of the literature

World Journal of Gastroenterology : WJG
Keita KaiOsamu Tokunaga

Abstract

A depressed lesion was found at a gastric angle of 76-year-old Japanese woman by esophagogastroduodenoscopy. Four years prior, she was diagnosed with a Helicobacter pylori infection but no eradication was performed. The pathological diagnosis of biopsy specimens was signet-ring cell carcinoma. Endoscopic submucosal dissection (ESD) was performed. Histopathological examination of the ESD specimen revealed proliferation of well-differentiated tubular adenocarcinoma mimicking fundic gland cells at the deep layer of the lamina propria mucosae. These tumor cells expressed focally pepsinogen-I, diffusely MUC6, and scattered H+/K+ ATPase according to immunohistochemistry. Therefore, we diagnosed this tumor as gastric adenocarcinoma of fundic gland type (GA-FG). Adjacent to the GA-FG, proliferation of signet-ring cell carcinoma which diffusely expressed MUC 2 and MUC 5AC was observed. Intestinal metaplasia was focally observed in the surrounding mucosa of the signet-ring cell carcinoma. To the best of our knowledge, this is the first case report of GA-FG with a signet-ring cell carcinoma component. The origin of signet-ring cell carcinoma, i.e., whether it accidentally arose from a non-neoplastic mucosa and coexisted with the GA-FG or ...Continue Reading

References

Jul 6, 2007·Pathology International·Tetsuya TsukamotoMasae Tatematsu
Apr 23, 2010·The American Journal of Surgical Pathology·Hiroya UeyamaSumio Watanabe
Dec 11, 2013·Digestive Endoscopy : Official Journal of the Japan Gastroenterological Endoscopy Society·Tetsuya UeoTetsuya Ishida
Dec 18, 2013·Endoscopy·Hiroya UeyamaSumio Watanabe
Jul 18, 2015·World Journal of Gastroenterology : WJG·Masaki MiyazawaYatsugi Noda
Oct 21, 2016·Digestive Endoscopy : Official Journal of the Japan Gastroenterological Endoscopy Society·Takashi ChibaDaisuke Shibuya
Nov 4, 2017·World Journal of Gastroenterology : WJG·Shigeo ManabeShuji Takahashi

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