PMID: 8583385Sep 1, 1995Paper

Gastric and duodenal anti-ulcer activity of SKF 38393, a dopamine D1-receptor agonist in rats

The Journal of Pharmacy and Pharmacology
J K DesaiN S Parmar

Abstract

The effect of SKF 38393 (1-phenyl-7,8-diol-2,3,4,5-tetrahydro-1H-3-benzazepine), a specific dopamine D1-receptor agonist, was studied on pylorus-ligation and water immersion plus restraint stress-induced gastric ulcers, and cysteamine-induced duodenal ulcers in rats. Repeated administration of SKF 38393 (5 and 10 mg kg-1, p.o.) for six days was found to be effective in the prevention of gastric ulceration induced by water immersion plus restraint stress in rats. In 19-h pylorus-ligated rats, repeated treatment with SKF 38393 showed a significant reduction in the number and severity of ulcers. SKF 38393 did not alter the total gastric-mucosal carbohydrates:protein ratio; however, the gastric content volume and the free and total acidity were significantly reduced. In cysteamine-induced duodenal ulcers, the treatment with SKF 38393 for 6 days prevented the duodenal lesions. Our data suggests the involvement of dopamine D1 receptors in the anti-ulcer activity of SKF 38393, which could be largely attributed to its anti-secretory effect. Its anti-ulcer activity against water immersion plus restraint, also points towards a central mode of action, but its failure to alter the carbohydrate:protein ratio rules out any protective effect ...Continue Reading

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Citations

May 29, 2008·Clinical and Experimental Pharmacology & Physiology·Afsaneh EliassiTaieb Ghasemi
Apr 22, 2008·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·S SinghG N Qazi
Jul 6, 2004·Journal of Ethnopharmacology·Poonam DharmaniGautam Palit
Aug 12, 2000·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·C J VaughanD P O'Connell

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