Gastric and intestinal phenotypic marker expression in gastric carcinomas and recurrence pattern after surgery-immunohistochemical analysis of 213 lesions

British Journal of Cancer
Y TajimaM Kusano

Abstract

Both gastric and intestinal phenotypic markers are known to be expressed in gastric carcinomas, irrespective of their histologic type. In the present study, the relation between gastric and intestinal phenotypic marker expression in gastric carcinomas and the recurrence pattern after surgery was examined. The phenotypic marker expression of the tumour was determined by examining the expression of human gastric mucin (HGM), MUC6, MUC2 and CD10 in 213 advanced gastric carcinomas in 213 patients who had undergone a curative resection (97 died from recurrent gastric carcinoma and 116 were alive without recurrence at the end of the follow-up period). Tumours were classified into gastric (G), gastric and intestinal mixed (GI), intestinal (I) or unclassified (UC) phenotypes according to the immunopositivity of HGM, MUC6, MUC2 and CD10 stainings. The incidence of HGM-positive tumours and MUC2-negative tumours was significantly higher in tumours with peritoneal recurrence than in tumours without recurrence (73.3%, 44 out of 60 cases vs 54.3%, 63 out of 116 (P=0.022); and 70.0%, 42 out of 60 vs 38.8%, 45 out of 116 (P=0.0002), respectively). The incidence of G-phenotype tumours was also significantly higher in tumours with peritoneal rec...Continue Reading

References

Apr 1, 1981·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·S M HsuH Fanger
Sep 1, 1995·Gastroenterology·Y S Kim, J R Gum
May 5, 1999·Pathology International·Y EgashiraM Ikegami
Feb 15, 2000·The British Journal of Surgery·C H YooJ S Min
Oct 23, 2001·International Journal of Cancer. Journal International Du Cancer·S TsukashitaT Hattori
May 7, 2002·International Journal of Cancer. Journal International Du Cancer·Séverine NolletJacques Bara
Mar 7, 2003·American Journal of Surgery·Satoshi OhnoNaofumi Nagasue
Aug 29, 2003·The British Journal of Surgery·F RovielloUNKNOWN Italian Research Group for Gastric Cancer

❮ Previous
Next ❯

Citations

Apr 24, 2012·American Journal of Clinical Pathology·Vincenzo CanzonieriLorenzo Memeo
Jan 5, 2007·Journal of Gastroenterology and Hepatology·Hiroaki Takeo, Susumu Matsukuma
Jul 13, 2006·Gastroenterology·Masahide FukayaHiroki Sasaki
Nov 3, 2006·Annals of Surgical Oncology·Stephan GretschelPeter M Schlag
Jan 30, 2009·Journal of Gastroenterology and Hepatology·Hye S HanYoung I Min
May 25, 2010·Journal of Gastroenterology and Hepatology·Kakunori BannoHidemi Goto
Mar 6, 2010·International Journal of Colorectal Disease·Shin FujitaMasayuki Ohue
Jun 4, 2008·Journal of Surgical Oncology·Kohei WakatsukiYoshiyuki Nakajima
Dec 6, 2014·Journal of Cancer Research and Clinical Oncology·Jung-Soo PyoJin Hee Sohn
Jan 19, 2013·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·Enrico SolciaRoberto Fiocca
Aug 1, 2015·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·Htoo Zarni OoWataru Yasui
Mar 28, 2012·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·Hiroki MurakamiYasuhiro Kodera
May 4, 2011·Virchows Archiv : an International Journal of Pathology·Achim FleischmannGeorge N Thalmann
Nov 7, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Yusuke TajimaMitsuo Kusano

❮ Previous
Next ❯

Methods Mentioned

BETA
dissection

Software Mentioned

Stat View

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.