Nov 1, 1974

Gastric and pancreatic responses to meals varying in pH

The Journal of Physiology
A DembinskiP Thor

Abstract

1. Gastric acid response to a test meal of 10% peptone was measured in chronic gastric and pancreatic fistula cats using the Fordtran and Walsh method, monitoring the rate at which a solution of 0.5 M sodium bicarbonate had to be added to maintain constant pH of gastric content at pre-selected values ranging from 5.0 to 1.0. Simultaneously, pancreatic secretion was determined by the standard collection technique. In this way the pH profile for the inhibition of gastric secretion and stimulation of pancreatic secretion has been established in cats.2. A peptone meal adjusted to pH 5.0 produced gastric acid output similar to the maximal response to histamine or pentagastrin. It provoked a negligible stimulation of pancreatic flow rate and bicarbonate output but a large protein output.3. Graded decrease of the peptone meal pH to below 4.0 resulted in inhibition of gastric acid production and in a concomitant stimulation of pancreatic secretory volume and bicarbonate output. A meal adjusted to pH 1.0 stimulated gastric secretion only about 30% of the response recorded at pH 5.0. Pancreatic secretion with a meal adjusted to pH 3.0 reached the highest level of about 70% of the maximal response to exogenous secretin.4. Since the observ...Continue Reading

  • References
  • Citations1

References

  • We're still populating references for this paper, please check back later.
  • References
  • Citations1

Mentioned in this Paper

Gastric Fistula
Gastric Juice
Laboratory Procedures
Gastric Content
Secretory Circumventricular Organs
Pancreatic Secretion Function
Food
Benign Tumor of Pancreas
Structure of Pyloric Gland
Secretin Measurement

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Coronavirus Protein Structures

Deciphering and comparing the proteins of different coronaviruses forms a basis for understanding SARS-CoV-2 evolution and virus-receptor interactions. This feed follows studies analyzing the structures of coronavirus proteins, thereby revealing potential drug target sites.

DDX3X Syndrome

DDX3X syndrome is caused by a spontaneous mutation at conception that primarily affects girls due to its location on the X-chromosome. DDX3X syndrome has been linked to intellectual disabilities, seizures, autism, low muscle tone, brain abnormalities, and slower physical developments. Here is the latest research.

ALS: Stress Granules

Amyotrophic Lateral Sclerosis (ALS) is a neurodegenerative disease characterized by cytoplasmic protein aggregates within motor neurons. TDP-43 is an ALS-linked protein that is known to regulate splicing and storage of specific mRNAs into stress granules, which have been implicated in formation of ALS protein aggregates. Here is the latest research.

Fusion Oncoproteins in Childhood Cancers

This feed explores the function of fusion oncoproteins in specific childhood cancers, including those from racial/ethnic minority and underserved groups, and to provide preclinical assessment of potential therapeutics and how fusion oncoproteins influence gene expression to perturb normal cellular programs to block lineage differentiation and development

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Regulation of Vocal-Motor Plasticity

Dopaminergic projections to the basal ganglia and nucleus accumbens shape the learning and plasticity of motivated behaviors across species including the regulation of vocal-motor plasticity and performance in songbirds. Discover the latest research on the regulation of vocal-motor plasticity here.

Mitotic-exit networks with cytokinesis

Cytokinesis is the highly regulated process that physically separates daughter and mother cells in late mitosis. The mitotic-exit network (MEN), the signalling pathway that drives mitotic exit, directly regulates cytokinesis. Discover the latest research on mitotic-exit networks with cytokinesis here.

DNA Replication Origin

DNA replication is initiated as specific gene sequences, called origins, that function to start DNA replication. Pre-replication complexes are assembled at these origins during the G1 phase of the cell cycle. These sequences allow for targeted activation or deactivation of replication. Discover the latest research on DNA replication origins here.