Gastric antiulcer, antisecretory and cytoprotective properties of celery (Apium graveolens) in rats

Pharmaceutical Biology
Tawfeq Al-HowirinyS Rafatullah

Abstract

In the present investigation, an ethanol extract of celery [Apium graveolens L. (Apiaceae/Umbelliferae)], at doses of 250 and 500 mg/kg body weight, was evaluated for antigastric ulcer activity using various experimental gastric ulcer models in rats. Ulcers were induced by indomethacin, cytodestructive agents (80% ethanol, 0.2 M NaOH and 25% NaCl) and cold restraint stress. Gastric secretory studies were undertaken by using pylorus ligation (Shay rat model). In addition to gastric wall mucus (GWM), non-protein sulfhydryl (NP-SH) and malondialdehyde (MDA) were also estimated in gastric tissues after 80% ethanol treatment. Pretreatment of celery extract produced dose-dependent reduction in all experimentally induced gastric lesions. Ethanol (80%) decreased the levels of GWM, NP-SH and increase in MDA concentration in gastric tissue. Celery extract showed the ability to significantly replenish the ethanol-induced depleted levels of GWM and gastric mucosal NP-SH. The gastric mucosal MDA level was also significantly lowered in extract pretreated rats. The celery extract showed stomach protection against the models used for ulcerogenesis. Results were further confirmed by using histopathological assessment. The phytochemical screenin...Continue Reading

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Citations

Jun 6, 2013·Journal of Medicinal Food·Maryam Hassanpour MoghadamSeyed Ahmad Mohajeri
Jun 4, 2013·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Rafael Porto IneuMaria Ester Pereira
Jan 15, 2015·Evidence-based Complementary and Alternative Medicine : ECAM·Abdulrahman K Al-AsmariSaeed M Al-Asmary
Feb 17, 2017·Journal of Natural Medicines·Phetcharat BoonruamkaewPennapa Chonpathompikunlert

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