Gastric bypass alters both glucose-dependent and glucose-independent regulation of islet hormone secretion

Obesity
Marzieh SalehiDavid A D'Alessio

Abstract

Roux-en-Y gastric bypass surgery (GB) is characterized by accentuated but short-lived postprandial elevations of blood glucose and insulin. This profile has been attributed to effects of relative hyperglycemia to directly stimulate β-cells and an augmented incretin effect. An additional glucose-independent stimulation of insulin secretion in GB subjects was hypothesized. Fifteen subjects with prior GB, six matched obese non surgical controls, and seven lean individuals were recruited. Islet hormones were measured before and after meal ingestion during hyperinsulinemic hypoglycemic clamps to minimize the direct effects of glycemia and glucose-dependent gastrointestinal hormones on insulin secretion. The GB subjects had less suppression of fasting β-cell secretion during the insulin clamp compared to controls. In addition, meal-induced insulin secretion increased in the GB subjects but not controls during fixed sub-basal glycemia. In contrast, the glucagon responses to hypoglycemia and meal ingestion were lower in the GB subjects than controls. Among subjects with GB, the response of insulin and glucagon secretion to decreasing blood glucose is blunted, but meal-induced insulin secretion is stimulated even at fixed systemic sub-b...Continue Reading

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Citations

May 14, 2016·Surgery for Obesity and Related Diseases : Official Journal of the American Society for Bariatric Surgery·Maud RobertLaurent Biertho
Sep 9, 2015·Obesity·Allison B Goldfine, Mary Elizabeth Patti
Aug 29, 2016·Surgery for Obesity and Related Diseases : Official Journal of the American Society for Bariatric Surgery·Francesco RubinoUNKNOWN Delegates of the 2nd Diabetes Surgery Summit
Nov 21, 2017·Diabetes, Obesity & Metabolism·Marzieh SalehiDavid A D'Alessio
Nov 1, 2017·International Journal of Obesity : Journal of the International Association for the Study of Obesity·A YaqubM Salehi
Mar 29, 2018·The Journal of Clinical Endocrinology and Metabolism·Esmeralda CapristoGeltrude Mingrone
Aug 14, 2018·The Journal of Clinical Endocrinology and Metabolism·Marzieh SalehiMary-Elizabeth Patti
May 15, 2019·Current Opinion in Clinical Nutrition and Metabolic Care·Henri Honka, Marzieh Salehi
Nov 13, 2019·The Journal of Clinical Endocrinology and Metabolism·Christopher M MullaMary Elizabeth Patti
Jun 24, 2016·The Journal of Clinical Endocrinology and Metabolism·Monica NannipieriEle Ferrannini
Jul 11, 2020·Chinese Medical Journal·Li-Yuan ZhouXin-Hua Xiao
May 26, 2016·Diabetes Care·Francesco RubinoUNKNOWN Delegates of the 2nd Diabetes Surgery Summit
Dec 14, 2016·Obesity Surgery·Francesco RubinoUNKNOWN Delegates of the 2nd Diabetes Surgery Summit
May 26, 2016·Diabetes Care·William T CefaluDavid E Cummings
Nov 27, 2020·Diabetes, Metabolic Syndrome and Obesity : Targets and Therapy·Amanda Sheehan, Mary Elizabeth Patti

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Methods Mentioned

BETA
X-ray

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SPSS

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