Gastric bypass increases energy expenditure in rats.

Gastroenterology
Marco BueterCarel W le Roux

Abstract

Mechanisms underlying weight loss maintenance after gastric bypass are poorly understood. Our aim was to examine the effects of gastric bypass on energy expenditure in rats. Thirty diet-induced obese male Wistar rats underwent either gastric bypass (n = 14), sham-operation ad libitum fed (n = 8), or sham-operation body weight-matched (n = 8). Energy expenditure was measured in an open circuit calorimetry system. Twenty-four-hour energy expenditure was increased after gastric bypass (4.50 +/- 0.04 kcal/kg/h) compared with sham-operated, ad libitum fed (4.29 +/- 0.08 kcal/kg/h) and sham-operated, body weight-matched controls (3.98 +/- 0.10 kcal/kg/h, P < .001). Gastric bypass rats showed higher energy expenditure during the light phase than sham-operated control groups (sham-operated, ad libitum fed: 3.63 +/- 0.04 kcal/kg/h vs sham-operated, body weight-matched: 3.42 +/- 0.05 kcal/kg/h vs bypass: 4.12 +/- 0.03 kcal/kg/h, P < .001). Diet-induced thermogenesis was elevated after gastric bypass compared with sham-operated, body weight-matched controls 3 hours after a test meal (0.41% +/- 1.9% vs 10.5% +/- 2.0%, respectively, P < .05). The small bowel of gastric bypass rats was 72.1% heavier because of hypertrophy compared with sham-...Continue Reading

References

Apr 1, 1987·The Journal of Clinical Investigation·E A Sims, E Danforth
Oct 1, 1996·Journal of Animal Science·J P CantW J Croom
Dec 1, 1996·Endocrinology and Metabolism Clinics of North America·F L Greenway
Apr 15, 2000·Nature·B B Lowell, B M Spiegelman
Apr 15, 2000·Nature·M W SchwartzD G Baskin
May 4, 2000·The Medical Clinics of North America·D B Allison, S E Saunders
Mar 29, 2001·Annual Review of Public Health·T L Visscher, J C Seidell
Feb 13, 2002·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·R D ConeM J Low
May 25, 2002·The New England Journal of Medicine·David E CummingsJonathan Q Purnell
Aug 9, 2002·Nature·Rachel L BatterhamStephen R Bloom
Jun 21, 2003·The American Journal of Clinical Nutrition·Sai Krupa DasEdward Saltzman
Jun 17, 2004·JAMA : the Journal of the American Medical Association·Allison A HedleyKatherine M Flegal
Oct 16, 2004·The Journal of Clinical Endocrinology and Metabolism·Judith KornerSharon L Wardlaw
Nov 6, 2004·Obesity Surgery·Henry Buchwald, Stanley E Williams
Mar 26, 2005·Science·Michael K Badman, Jeffrey S Flier
Nov 11, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Claudio Acuna-Goycolea, Anthony N van den Pol
Nov 23, 2005·International Journal of Obesity : Journal of the International Association for the Study of Obesity·E NadreauD Richard
May 16, 2006·Physiology & Behavior·Thomas A Lutz
Dec 15, 2006·Nature·Kevin G Murphy, Stephen R Bloom
Dec 19, 2006·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Björn StenströmDuan Chen
Apr 13, 2007·Physiology & Behavior·Peter Y WielingaThomas A Lutz
Jul 13, 2007·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Ana GuijarroMichael M Meguid
Aug 24, 2007·The New England Journal of Medicine·Lars SjöströmUNKNOWN Swedish Obese Subjects Study
Aug 24, 2007·The New England Journal of Medicine·Ted D AdamsSteven C Hunt
Sep 15, 2007·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Christine MackDavid Parkes
Oct 31, 2007·Annals of Surgery·Carel W le RouxTorsten Olbers
Feb 6, 2008·Obesity Surgery·Marianne W FurnesDuan Chen
Mar 6, 2008·Obesity Surgery·Marcelo de Castro CesarGabrielle Aparecida Cardoso
Mar 24, 2009·Journal of Human Nutrition and Dietetics : the Official Journal of the British Dietetic Association·S D AntonD A Williamson
Apr 21, 2009·The American Journal of Medicine·Michael A TrakhtenbroitHeinrich Taegtmeyer

❮ Previous
Next ❯

Citations

Aug 27, 2011·Langenbeck's Archives of Surgery·M GassR Peterli
Sep 23, 2011·International Journal of Obesity : Journal of the International Association for the Study of Obesity·K A Sharkey
Sep 23, 2011·International Journal of Obesity : Journal of the International Association for the Study of Obesity·M Bueter, C W le Roux
Sep 23, 2011·International Journal of Obesity : Journal of the International Association for the Study of Obesity·D Sandoval
Oct 10, 2012·International Journal of Obesity : Journal of the International Association for the Study of Obesity·N SaeidiN Stylopoulos
Feb 20, 2013·International Journal of Obesity : Journal of the International Association for the Study of Obesity·C DirksenD L Hansen
Apr 10, 2013·International Journal of Obesity : Journal of the International Association for the Study of Obesity·N N AhmadL M Kaplan
Mar 29, 2013·Science Translational Medicine·Alice P LiouLee M Kaplan
Jul 8, 2011·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Carel W le RouxThomas A Lutz
Dec 16, 2011·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·C M MathesA C Spector
Sep 29, 2011·Journal of Obesity·Keisuke SuzukiStephen R Bloom
May 3, 2012·Endocrine Reviews·Margaret A StefaterRandy J Seeley
Jun 19, 2013·PloS One·Carl Frederik HansenJacob Jelsing
Feb 27, 2014·Current Cardiology Reports·Rodrigo Muñoz, Alex Escalona
Oct 30, 2013·International Journal of Obesity : Journal of the International Association for the Study of Obesity·A R RamzyP K Chelikani
Nov 12, 2013·International Journal of Obesity : Journal of the International Association for the Study of Obesity·A D Miras, C W le Roux
Aug 28, 2013·Annals of Surgery·Marco RaffaelliGeltrude Mingrone
Sep 25, 2012·Current Atherosclerosis Reports·Dimitrios PapamargaritisCarel W le Roux
Apr 25, 2012·Obesity Surgery·F SeyfriedC W le Roux
Aug 18, 2012·Experimental Diabetes Research·Keisuke SuzukiStephen R Bloom
Feb 11, 2014·Surgery for Obesity and Related Diseases : Official Journal of the American Society for Bariatric Surgery·Silvia Leite FariaCynthia Buffington
May 18, 2012·Obesity Surgery·Silvia Leite FariaHeloisa Rodrigues de Gouvêa
Oct 6, 2014·Surgery for Obesity and Related Diseases : Official Journal of the American Society for Bariatric Surgery·Malin WerlingTorsten Olbers
Oct 15, 2014·Der Chirurg; Zeitschrift für alle Gebiete der operativen Medizen·C CortevilleM Bueter
Jun 20, 2012·Journal of Visualized Experiments : JoVE·Marco BueterCarel W le Roux
Dec 12, 2012·Obesity Surgery·David ThivelBlandine Laferrère
Jan 23, 2013·Journal of Proteome Research·Florian SeyfriedElaine Holmes
Nov 2, 2011·Obesity Facts·Florian SeyfriedMarco Bueter
Jun 23, 2012·Obesity Facts·Lars FischerBeat Müller-Stich
Feb 14, 2013·Current Opinion in Endocrinology, Diabetes, and Obesity·Florencia Halperin, Allison B Goldfine
Jul 10, 2013·Nature Reviews. Gastroenterology & Hepatology·Alexander D Miras, Carel W le Roux
Jun 23, 2011·International Journal of Obesity : Journal of the International Association for the Study of Obesity·W K FenskeC W le Roux
Nov 30, 2011·International Journal of Obesity : Journal of the International Association for the Study of Obesity·A LaureniusT Olbers

❮ Previous
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