Gastric cancer: an update.

Current Oncology Reports
Manish A Shah

Abstract

Gastric cancer is an aggressive malignancy, which, if metastatic or unresectable, is incurable. However, with metastatic or unresectable disease, patients receive a palliative benefit from chemotherapy. Although the understanding of the biology of this disease is increasing, the development of biologically targeted therapies for gastric cancer has been limited. Cytotoxic therapy remains the standard approach, and although there is agreement on the active agents and active combination chemotherapy regimens, consensus on the standard or reference regimen is lacking. This article reviews the pathophysiology of this disease, placing it in the context of its epidemiology, and the current advances in the treatment of this disease.

References

Jun 1, 1992·Gastroenterology·G J OfferhausS R Hamilton
Nov 15, 1968·International Journal of Cancer. Journal International Du Cancer·N MuñozE Duque
Dec 16, 1998·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·L B SaltzD Kelsen
Aug 24, 1999·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·N BokuI Hyodo
Oct 3, 1999·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·D H IlsonD P Kelsen
Apr 26, 2000·Cancer Letters·T YoshikawaY Noguchi
Mar 16, 2001·Annals of Oncology : Official Journal of the European Society for Medical Oncology·K RidwelskiH Lippert
Jul 10, 2001·Acta Oncologica·K G JanungerUNKNOWN SBU-group. Swedish Council of Technology Assessment in Health Care
Sep 22, 2001·The Annals of Thoracic Surgery·T A AloiaT A D'Amico
Oct 17, 2001·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·D M ParkinS S Devesa
Dec 1, 2001·Expert Opinion on Biological Therapy·M R Anderson, J A Jankowski
May 29, 2002·Alimentary Pharmacology & Therapeutics·Matthias P A Ebert, P Malfertheiner
Nov 28, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·C LouvetA de Gramont
Dec 31, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Atsushi OhtsuUNKNOWN Japan Clinical Oncology Group Study (JCOG9205)
Feb 25, 2003·Annals of Oncology : Official Journal of the European Society for Medical Oncology·D Y KimN K Kim
May 2, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Matthias P A EbertPeter Malfertheiner
May 24, 2003·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·P CholletUNKNOWN EORTC Early Clinical Studies Group
May 31, 2003·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·Ikuo TakahashiYoshihiko Maehara
Jun 7, 2003·Recent Results in Cancer Research. Fortschritte Der Krebsforschung. Progrès Dans Les Recherches Sur Le Cancer·Reinhard KoppAndreas Pfeiffer
Jan 1, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Udo VanhoeferJosé Baselga
Aug 7, 2004·Seminars in Oncology·Manish A Shah, Gary K Schwartz
Nov 30, 2004·Science·Jeanmarie HoughtonTimothy C Wang
Jan 22, 2005·CA: a Cancer Journal for Clinicians·Ahmedin JemalMichael J Thun
Mar 30, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Manish A ShahDavid P Kelsen
Apr 30, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·James C YaoJaffer A Ajani
Sep 8, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Jaffer A AjaniPeter Urrea
Nov 24, 2005·Annals of Oncology : Official Journal of the European Society for Medical Oncology·A JatoiUNKNOWN North Central Cancer Treatment Group
Sep 12, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Federico RojoJosé Baselga

❮ Previous
Next ❯

Citations

Dec 1, 2010·Pathology Oncology Research : POR·Andrea Rodrigues GonçalvesHeitor Siffert Pereira de Souza
Oct 28, 2008·BMC Medical Genomics·Oi Lian KonM Priyanthi Kumarasinghe
Aug 12, 2019·Indian Journal of Gastroenterology : Official Journal of the Indian Society of Gastroenterology·D K S KannangaraR S Dassanayake

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.