Gastric Cancer: Epidemiology, Risk Factors, Classification, Genomic Characteristics and Treatment Strategies.

International Journal of Molecular Sciences
Julita MachlowskaRobert Sitarz

Abstract

Gastric cancer (GC) is one of the most common malignancies worldwide and it is the fourth leading cause of cancer-related death. GC is a multifactorial disease, where both environmental and genetic factors can have an impact on its occurrence and development. The incidence rate of GC rises progressively with age; the median age at diagnosis is 70 years. However, approximately 10% of gastric carcinomas are detected at the age of 45 or younger. Early-onset gastric cancer is a good model to study genetic alterations related to the carcinogenesis process, as young patients are less exposed to environmental carcinogens. Carcinogenesis is a multistage disease process specified by the progressive development of mutations and epigenetic alterations in the expression of various genes, which are responsible for the occurrence of the disease.

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Citations

Jan 2, 2021·International Journal of Molecular Sciences·Joanna KozakJacek Baj
Feb 2, 2021·Technology in Cancer Research & Treatment·Qiang ZhouKai Liu
Nov 19, 2020·Clinical Journal of Gastroenterology·Alicja FormaMonika Sitarz
Nov 16, 2020·BMC Gastroenterology·Qiang-Ping ZhouCheng-Yuan Liu
Mar 25, 2021·Journal of Gastrointestinal Cancer·Magdalena TyczyńskaAlicja Forma
Apr 8, 2021·Biomedical Engineering Online·Yankai ZhangYingjiang Ye
Apr 24, 2021·Journal of Gastrointestinal Cancer·Dariush KarimiTouraj Asvadi Kermani
Jun 3, 2021·International Journal of Molecular Sciences·Laura Francesca PisaniLuca Pastorelli
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Aug 31, 2021·World Journal of Gastrointestinal Oncology·Petar RasicDjordje Savic
Sep 4, 2021·Journal of Gastrointestinal Cancer·Maryam GholamalizadehNaser Kalantari
Sep 10, 2021·Journal of Gastrointestinal Cancer·Afrooz MazidimoradiHamid Salehiniya
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Nov 19, 2021·Frontiers in Cell and Developmental Biology·Zhifu GuiYuting Kuang
Nov 23, 2021·Phytotherapy Research : PTR·Yudong ZhengKwang Seok Ahn

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Methods Mentioned

BETA
biopsies
dissection
surgical resection

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