PMID: 11916345Mar 28, 2002Paper
Gastric cancer in sub-Saharan Africa
European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)
I SegalH Mitchell
Abstract
Gastric cancer has a variable but generally low prevalence in black populations of sub-Saharan Africa, despite a high prevalence of Helicobacter pylori (the 'African enigma'). Evidence from Soweto indicates that the host response to H. pylori may be protective against a virulent organism and that, in most people, H. pylori does not lead to more serious sequelae. This suggests that there may be host protective/inhibitory factors present, which prevent the progression of H. pylori-induced chronic active gastritis to cancer.
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