Gastric cancer-secreted exosomal X26nt increases angiogenesis and vascular permeability by targeting VE-cadherin.

Cancer Science
Xiaocui ChenLisong Shen

Abstract

Angiogenesis is closely associated with tumorigenesis, invasion, and metastasis by providing oxygen and nutrients. Recently, increasing evidence indicates that cancer-derived exosomes which contain proteins, coding, and noncoding RNAs (ncRNAs) were shown to have proangiogenic function in cancer. A 26-nt-long ncRNA (X26nt) is generated in the process of inositol-requiring enzyme 1 alpha (IRE1α)-induced unspliced XBP1 splicing. However, the role of X26nt in the angiogenesis of gastric cancer (GC) remains largely unknown. In the present study, we found that X26nt was significantly elevated in GC and GC exosomes. Then, we verified that X26nt could be delivered into human umbilical vein endothelial cells (HUVECs) via GC cell exosomes and promote the proliferation, migration, and tube formation of HUVECs. We revealed that exosomal X26nt decreased vascular endothelial cadherin (VE-cadherin) by directly combining the 3'UTR of VE-cadherin mRNA in HUVECs, thereby increasing vascular permeability. We further demonstrated that X26nt accelerates the tumor growth and angiogenesis in a mouse subcutaneous tumor model. Our findings investigate a unique intercellular communication mediated by cancer-derived exosomes and reveal a novel mechanism ...Continue Reading

References

Aug 1, 1995·Arteriosclerosis, Thrombosis, and Vascular Biology·F BreviarioE Dejana
Aug 15, 1996·The Journal of Clinical Investigation·L CavedaE Dejana
Mar 14, 1998·Experimental Cell Research·T L BachJ Martinez
Aug 18, 1999·Proceedings of the National Academy of Sciences of the United States of America·M CoradaE Dejana
Jul 23, 2004·Physiological Reviews·Gianfranco Bazzoni, Elisabetta Dejana
Sep 3, 2004·Cancer Research·Lorenzo Romero-RamirezAlbert C Koong
Jan 22, 2005·Current Opinion in Genetics & Development·Peter BalukDonald M McDonald
Dec 16, 2005·Nature·Napoleone Ferrara, Robert S Kerbel
May 7, 2009·Proceedings of the National Academy of Sciences of the United States of America·Lingfang ZengQingbo Xu
Jul 6, 2010·Journal of Proteomics·Suresh MathivananRichard J Simpson
Mar 7, 2012·Cold Spring Harbor Perspectives in Medicine·Andrew C Dudley
Nov 28, 2012·The Journal of Biological Chemistry·Andriana MargaritiLingfang Zeng
Aug 30, 2013·Scientific Reports·Eleonora LeucciAnders H Lund
Sep 21, 2013·Developmental Cell·Monica GiannottaElisabetta Dejana
Jan 1, 2015·Heart Failure Reviews·Wang ZhaoShui-Ping Zhao
Sep 1, 2015·Arteriosclerosis, Thrombosis, and Vascular Biology·Lingfang ZengQingbo Xu
Nov 3, 2015·Nature·Ayuko HoshinoDavid Lyden
Dec 4, 2016·Advanced Drug Delivery Reviews·Jayoung KimJordan J Green
Dec 9, 2016·Future Oncology·Ramon Andrade de MelloGeorgios Antoniou
May 20, 2017·Cell Research·Paul Kurywchak, Raghu Kalluri
Jul 4, 2017·International Journal of Cancer. Journal International Du Cancer·Khondoker Jahengir AlamSoo-Cheon Chae
Jul 4, 2017·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Zheyu SongXuedong Fang
Jan 22, 2018·Experimental Cell Research·Junyao YangLisong Shen
Feb 13, 2018·Cellular and Molecular Life Sciences : CMLS·Noel A WarrenAnastasios Georgakopoulos
Feb 27, 2018·The Journal of Clinical Investigation·Na ZhaoXi Chen
Jun 13, 2018·Nature Communications·Maggie K S TangAlice S T Wong
Jan 16, 2019·The Journal of Immunology : Official Journal of the American Association of Immunologists·Xiaocui ChenJu Liu
Mar 17, 2019·Molecular Cancer·Min FuXu Zhang

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