PMID: 2494803Jan 1, 1989Paper

Gastric carcinoma with lymphoid stroma. Analysis using mucin histochemistry and immunohistochemistry

Virchows Archiv. A, Pathological Anatomy and Histopathology
N Lertprasertsuke, Y Tsutsumi

Abstract

A total of 626 surgically resected gastric carcinomas were reviewed, and 24 cases (3.8%) of "gastric carcinoma with lymphoid stroma" were identified. The tumour cells were consistently arranged in an anastomosing trabecular or alveolar pattern and were densely infiltrated by lymphoid cells. The specimens were studied using mucin histochemistry and the indirect immunoperoxidase method to determine the histochemical properties of this form of gastric carcinoma. The tumour cells were consistently positive for concanavalin A paradoxical staining, class III and almost devoid of acidic mucins, features demonstrating preferential differentiation toward pyloric glands or pseudopyloric glands. Immunohistochemically, positive reactions for Leu M1 and lysozyme, marker substances of (pseudo)pyloric gland cells, were often observed. Carcinoembryonic antigen was positive in focal areas without (pseudo)pyloric glandular patterns. Secretory component was focally positive. HLA-DR was strongly expressed in most cancer cells and 17 tumours (71%) showed positivity for interleukin 1 (IL-1). The lymphoid stroma contained a high percentage of UCHL1-reactive T cells both within and around the cancer cell nests, while SL26-reactive B cells clustered in...Continue Reading

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Citations

Jun 29, 1999·Surgery Today·T YamadaH Matsunou
Nov 28, 2012·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·Mototsugu FujiiYuro Shibayama
Aug 7, 2003·The Annals of Thoracic Surgery·Freddy Angulo-Pernett, W Roy Smythe
May 1, 1996·The American Journal of Surgical Pathology·G ZamboniF Menestrina
Apr 7, 1999·Journal of Clinical Gastroenterology·H KijimaY Ueyama
Feb 24, 2015·International Journal of Colorectal Disease·Fernando Macias-GarciaJ Enrique Dominguez-Muñoz
Nov 23, 2013·The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi·Dae Hyun TakSun Hyung Kang
Sep 1, 1995·Pathology International·Y OgawaY Tsutsumi
Feb 18, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Josine van BeekElisabeth Bloemena
Feb 14, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Y WadaM Kojiro
Mar 6, 2004·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Y EgashiraY Shibayama
Aug 13, 2015·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·Byung-Hoon MinKyoung-Mee Kim
Oct 7, 2006·Current Opinion in Gastroenterology·G A Macdonald

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