Gastric cardia adenocarcinoma microRNA profiling in Chinese patients

Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine
Shegan GaoXiaoshan Feng

Abstract

Gastric cardia adenocarcinoma (GCA), which occurs at the gastroesophageal boundary, is one of the most malignant types of cancer. Over the past 30 years, the incidence of GCA has increased by approximately sevenfold, which has a more substantial increase than that of many other malignancies. However, as previous studies mainly focus on non-cardia gastric cancer, until now, the mechanisms behind GCA remain largely unknown. MicroRNAs (miRNAs) have been shown to play pivotal roles in carcinogenesis. To gain insight into the molecular mechanisms regulated by miRNAs in GCA development, we investigated miRNA expression profiles using 81 pairs of primary GCAs and corresponding non-tumorigenic tissues. First, 21 pairs of samples were used for microarray analysis, and then another 60 pairs of samples were used for further analysis. Our results showed that 464 miRNAs (237 upregulated, 227 downregulated, false discovery rate FDR <0.05) were differently expressed between GCA and non-tumor tissues. Pearson test and pathway analysis revealed that these dysregulated miRNA correlated coding RNAs may have effects on several cancer-related pathways. Four miRNAs (miR-1244, miR-135b-5p, miR-3196, and miR-628-3p) were found to be associated with GC...Continue Reading

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Citations

Nov 5, 2016·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Wenzhe WangShenglin Ma
Aug 12, 2017·Cancer Biomarkers : Section a of Disease Markers·Guang-Wei LiuQin-Hai Shen
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Dec 12, 2017·The Prostate·Agnieszka PaziewskaJerzy Ostrowski
May 19, 2020·Technology in Cancer Research & Treatment·Guo ChenRui Li
May 12, 2020·Cancer Biomarkers : Section a of Disease Markers·Jingjing LvXiaojuan Jia
May 5, 2020·Dose-response : a Publication of International Hormesis Society·Fusheng LiRenyi Zhou
Oct 15, 2019·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Leslimar Rios-ColonDeepak Kumar
Jun 21, 2019·Journal of Diabetes Research·Jianqin WangXiaochun Zhou
Aug 23, 2016·World Journal of Gastroenterology : WJG·Meng Zhang, Xiang Du
Sep 11, 2018·Cancer Biomarkers : Section a of Disease Markers·Juan WangWenfang Cheng

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