Gastric collision tumor of large cell neuroendocrine carcinoma and adenocarcinoma--a case report

Pathology, Research and Practice
Kyu Yun JangHo Sung Park

Abstract

Large cell neuroendocrine carcinomas (LCNECs) of the stomach are rare and represent only a small percentage of all gastric endocrine tumors. Here we report a case of a rare combination of gastric LCNEC concurrent with gastric adenocarcinoma. A 50-year-old man presented with heartburn sensation for 2 weeks. An endoscopic evaluation revealed a relatively well-demarcated ulcerative elevated lesion at the lower body of the stomach. Grossly, the gastric mass was a 5x4.5 cm-sized ulcerative fungating lesion. Microscopically, two separated lesions were recognized. The main lesion showed neuroendocrine morphology, such as nests and trabeculae. Most of the tumor cells had large, vesicular nuclei with prominent eosinophilic nucleoli, variable amounts of eosinophilic cytoplasm, and immunoreactivity for synaptophysin and chromogranin A. The other lesion was a well-differentiated adenocarcinoma of early gastric cancer type IIa located adjacent mucosa of the main lesion. We diagnosed this lesion as gastric LCNEC concurrent with focal adenocarcinoma, collision type.

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Citations

Oct 20, 2010·Journal of Gastrointestinal Cancer·Tarun RustagiTodd J Alekshun
Oct 20, 2012·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Tsutomu NamikawaKazuhiro Hanazaki
Mar 17, 2012·Clinical Colorectal Cancer·Paul E ObersteinM Wasif Saif
Aug 24, 2011·Clinical Colorectal Cancer·Derek G PowerEileen M O'Reilly
Mar 15, 2015·Gastroenterology Research and Practice·Adamantios MichalinosMichael Kontos
Apr 26, 2014·Journal of Gastric Cancer·Giovanni Battista Levi SandriAlfredo Garofalo
Apr 2, 2015·Medical Molecular Morphology·Jun TaguchiHirohisa Yano
May 13, 2021·Case Reports in Gastroenterology·Kimitoshi KuboMototsugu Kato

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