PMID: 11338065May 8, 2001Paper

Gastric corpus atrophy following eradication of Helicobacter pylori

European Journal of Gastroenterology & Hepatology
C J LarkinK D Buchanan

Abstract

Atrophic gastritis can develop in patients with Helicobacter pylori infection leading to a reduction in basal acid output. Whether the atrophy that develops is reversible is controversial. To investigate the effect of H. pylori eradication in infected subjects who had developed atrophy of the corpus mucosa. Ten H. pylori positive patients with corpus atrophy were identified at oesophagogastroduodenoscopy (OGD). They received eradication therapy with amoxicillin, clarithromycin and omeprazole. Repeat OGD with biopsy was performed at least 3 months later. Fasting plasma gastrin was measured at baseline and at re-endoscopy. H. pylori eradication was confirmed by 13C urea breath testing. Median time to re-endoscopy was 5 months. There was improvement in corpus atrophy in 50% of patients after H. pylori eradication, and a significant reduction in plasma gastrin (P = 0.03). The index patients had a significant diminution of basal acid output compared to controls. Corpus atrophy as defined by the Sydney System is reversible in some patients after H. pylori eradication. Improvement in atrophy is associated with a fall in fasting plasma gastrin levels. This may have implications in the prevention of gastric carcinoma.

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Citations

Aug 23, 2005·Digestive Diseases and Sciences·Barik A SalihErsan Sander
Nov 7, 2001·Current Gastroenterology Reports·E J Kuipers, T A Grool
Sep 5, 2002·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Takashi KobayashiSaburo Nakazawa
Jan 19, 2007·Alimentary Pharmacology & Therapeutics·L FuccioF Bazzoli
Sep 26, 2006·Best Practice & Research. Clinical Gastroenterology·Peter MalfertheinerKlaus Mönkemüller
Sep 1, 2005·The American Journal of Gastroenterology·Peter MalfertheinerUNKNOWN Lejondal H. pylori-Gastric Cancer Task Force
Jul 9, 2005·European Journal of Gastroenterology & Hepatology·Kazimierz RembiaszJerzy Stachura
Sep 24, 2005·Digestion·Yuji NaitoHidekazu Suzuki

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Atrophic Gastritis

Atrophic Gastritis is a process where gastric glandular cells are lost and replaced with firbous tissues, as a result of chronic inflammation. Learn more about Atrophic Gastritis here.