Abstract
Previous reports have shown that gastric epithelial dysplasia (GED) limited to the crypt (gastric crypt dysplasia, GCD) is commonly identified at the periphery of gastric carcinoma. However, it is unknown whether GCD is endoscopically identifiable, and how it relates to classic GED lesions. We investigated 1196 consecutive endoscopic resections of GED lesions between January 2011 and December 2014. We also evaluated clinicopathological features of these lesions, as well as the immunohistochemical expression of mucin (Muc)2, Muc5AC, Muc6, CD10, Ki67 and p53. We found 51 (4.3%) lesions composed microscopically of GCD among 1196 GED lesions. Those were elevated mucosal lesions (66.7%) similar in colour and texture to the adjacent mucosa (68.6%). GCD was likely to have an antropyloric location and a higher grade than the adenomatous type, similar to the foveolar and hybrid types (P < 0.05). A gastric immunophenotype was more common in GCD compared to adenomatous GED (P < 0.05). Ki-67- and p53-positive cells were more evident in GCD compared to the adjacent gastric mucosa. Our results demonstrated that GCD can be an endoscopically identifiable lesion, sharing many similarities with foveolar and hybrid GED, for which it may represent...Continue Reading
References
Apr 15, 1986·Cancer·T Hattori
May 1, 1996·The Journal of Pathology·A ImataniH Nagura
Oct 13, 1999·Gut·G Y Lauwers, R H Riddell
Oct 23, 2001·International Journal of Cancer. Journal International Du Cancer·S TsukashitaT Hattori
Oct 3, 2002·The American Journal of Surgical Pathology·Susan C AbrahamTsung-Teh Wu
Mar 14, 2003·The Journal of Pathology·Hiroshi KawachiMorio Koike
Apr 19, 2003·Journal of Clinical Gastroenterology·Gregory Y Lauwers
Jan 8, 2005·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Toru NiwaMasae Tatematsu
Apr 21, 2006·The American Journal of Surgical Pathology·Leslie C LomoRobert D Odze
Sep 5, 2006·Human Pathology·Francesca TavaEnrico Solcia
Feb 28, 2008·The American Journal of Surgical Pathology·Do Youn ParkGregory Y Lauwers
Aug 2, 2008·The American Journal of Surgical Pathology·Xiaoqi ZhangRobert D Odze
Jun 17, 2011·The American Journal of Surgical Pathology·Nari ShinDo Youn Park
Oct 20, 2012·Human Pathology·Yuan LiGregory Y Lauwers
May 23, 2013·The Journal of Pathology·Shabuddin KhanSebastian Zeki
Aug 1, 2013·Archives of Pathology & Laboratory Medicine·Dae Hwan KimDo Youn Park
Feb 18, 2014·Human Pathology·Agoston T Agoston, Robert D Odze