PMID: 7034158Jan 1, 1981Paper

Gastric cytoprotection in man by prostaglandin E2

Scandinavian Journal of Gastroenterology
H RuppinW Domschke

Abstract

In healthy volunteers, the effects of topical prostaglandins E2 (PGE2), 1 mg, on transmucosal potential difference (PD), mucus secretion, and epithelial cell turnover were investigated. PGE2 increased gastric PD by 10 mV on an average and stimulated mucus secretion of the stomach by 50%. In contrast, epithelial cell turnover remained unchanged. Gastric output of H+ decreased, whereas the outputs of volume, Na+, and Cl- rose in response to PGE2, which effects would be compatible with increased secretion of bicarbonate. Topical administration of ethanol 40% (vol/vol) reduced PD by 25 mV (delta PDE) and enhanced epithelial cell shedding by 350% with concomitant discharge of mucus from stomach epithelium. Pretreatment of the stomach with 1 mg PGE2 prevented the ethanol-dependent epithelial cell exfoliation, indicating gastric mucosal cytoprotection. Delta PDE and discharge of mucus were not significantly altered by PGE2. We conclude that gastric cytoprotection by PGE2 in man might be mediated by stimulation of mucus and/or bicarbonate production.

References

Dec 9, 1978·Lancet·M M Cohen
Feb 10, 1979·Lancet·C JohanssonS Bergström
Jun 1, 1979·European Journal of Clinical Investigation·C Johansson, B Kollberg
Jan 1, 1978·Scandinavian Journal of Gastroenterology·J Rybicka, K Gibiński
Apr 1, 1978·The American Journal of Digestive Diseases·J P BoltonM M Cohen
Jan 1, 1972·Scandinavian Journal of Gastroenterology·W DomschkeL Demling
Sep 1, 1974·The American Journal of Digestive Diseases·Y J KuoT J Sernka
Feb 1, 1968·Gut·M J Langman
Apr 21, 1970·Biochimica Et Biophysica Acta·L W Way, J M Diamond
May 1, 1959·The Journal of Clinical Investigation·L WARREN

❮ Previous
Next ❯

Citations

Feb 1, 1986·Digestive Diseases and Sciences·S J Konturek, W Pawlik
Nov 1, 1985·Digestive Diseases and Sciences·G L Kauffman
Nov 1, 1985·Digestive Diseases and Sciences·E R Lacy
Oct 1, 1983·Digestive Diseases and Sciences·J N HuntL Kessler
Feb 1, 1984·Digestive Diseases and Sciences·M J Derelanko, F Gavigan
Nov 1, 1980·Digestive Diseases and Sciences·T K Chaudhury, A Robert
Jan 7, 2000·Irish Journal of Medical Science·A A ShahF E Murray
Jun 1, 1984·Clinical Biochemistry·J L WallaceM M Cohen
Jan 1, 1987·Scandinavian Journal of Rheumatology·L B SvendsenF Stener Jørgensen
Jan 1, 1985·Scandinavian Journal of Gastroenterology. Supplement·C JohanssonA Uribe
Nov 15, 1997·Scandinavian Journal of Gastroenterology·J W KonturekW Domschke
Jan 1, 1983·Scandinavian Journal of Gastroenterology·S DomschkeW Domschke
Oct 1, 1991·Scandinavian Journal of Gastroenterology·M Leivonen, E Kivilaakso
Jun 1, 1985·Scandinavian Journal of Gastroenterology·S J Konturek
Jan 1, 1986·Scandinavian Journal of Gastroenterology. Supplement·R ArnoldB Willemer
Jan 1, 1986·Scandinavian Journal of Gastroenterology. Supplement·W DomschkeB Kaduk
Nov 1, 1985·Journal of Clinical Pharmacology·N CharletR J Wills
Dec 1, 1987·Alimentary Pharmacology & Therapeutics·C J Hawkey
Jan 1, 1989·Scandinavian Journal of Gastroenterology. Supplement·M M Cohen
Oct 1, 1988·Gastroenterologia Japonica·I DobóI Rózsa

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.