Gastric dysmotility in healthy first-degree relatives of patients with schizophrenia

Progress in Neuro-psychopharmacology & Biological Psychiatry
Sandy BergerKarl-Jürgen Bär

Abstract

Gastric dysmotility has been reported in patients suffering from major depression or schizophrenia. An increased sympathetic activity modulating the gastric pacemaker located in the antrum of the stomach has been suggested as the underlying pathology. Similar to patients suffering from schizophrenia, their first-degree relatives showed alterations in cardiac autonomic modulation. Here we aimed to investigate gastric myoelectrical activity in healthy relatives of patients suffering from paranoid schizophrenia. Electrogastrography (EGG) was performed before and after test meal ingestion in 20 patients with paranoid schizophrenia, 20 of their first-degree relatives and 20 healthy matched controls. Autonomic and abdominal symptoms were assessed by the autonomic symptom score as previously reported. Autonomic parameters were correlated with the positive and negative syndrome scale (PANSS). Only minimal differences were observed before test meal ingestion between relatives and controls. In contrast, after test meal ingestion we observed a significantly increased tachygastria within the signal of the gastric pacemaker in relatives compared to controls, whereas normogastria was reduced. Significant difference between relatives and cont...Continue Reading

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Citations

Jul 9, 2013·Indian Journal of Psychological Medicine·Parthasarathy RamamourthyShivanand Kattimani
Jun 10, 2011·Progress in Neuro-psychopharmacology & Biological Psychiatry·Sandy BergerKarl-Jürgen Bär
Aug 2, 2014·Therapeutic Advances in Psychopharmacology·Birmay Cam, Mehmet Zeki Tanircan
Dec 13, 2017·CNS Drugs·Dan Cohen
May 27, 2020·Asia-Pacific Psychiatry : Official Journal of the Pacific Rim College of Psychiatrists·Wei-Chia HuangWei-Lieh Huang
Mar 1, 2013·Clinical Schizophrenia & Related Psychoses·Hulegar A AbhishekhTalakad N Sathyaprabha
Nov 23, 2020·Schizophrenia Research·Alexander RefischKarl-Jürgen Bär

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