Gastric effects of mu-, delta- and kappa-opioid receptor agonists on brainstem unitary responses in the neonatal rat

European Journal of Pharmacology
C S Yuan

Abstract

Single units in the medial subnucleus of the nucleus tractus solitarii, responding to electrical stimulation of subdiaphragmatic vagal fibers, were recorded extracellularly in an in vitro neonatal rat brainstem-gastric preparation. Selective opioid receptor agonists were applied only to the gastric compartment of the bath chamber and therefore, the brainstem functions of the preparation were not affected. The peripheral gastric effects of the mu-opioid receptor agonist, [D-Ala2, N-MePhe4, Gly5-ol]enkephalin (DAMGO) and kappa-opioid receptor agonist, ¿trans-3,4-dichloro-N-methyl-N-[2-(l-pyrrolidinyl)cyclohexyl]cyclohexyl] benzeneacetamide methanesulfonate hydrate¿ (U-50, 488H), were evaluated on 69 units that received the subdiaphragmatic vagal input. For approximately 75% of the units observed, DAMGO (1.0 microM; IC70; 80 nM) and U-50, 488H (1.0 microM; IC70:200 nM) induced a concentration-dependent inhibition of 62.7 +/- 8.9% (mean +/- S.D.) and 50.6 +/- 6.2% of the control level of the brainstem neuronal activity, respectively. The mu-opioid selective receptor antagonist, naltrexone and non-selective opioid receptor antagonist, naloxone, respectively, blocked the inhibitory effects by DAMGO and U-50, 488 H. The delta-opioid r...Continue Reading

References

Sep 1, 1990·Journal of the Autonomic Nervous System·C S Yuan, W D Barber
Jan 1, 1988·Life Sciences·T F BurksF Porreca
Mar 1, 1985·Neuropharmacology·D R Brown, L I Goldberg
Jan 1, 1985·Annual Review of Pharmacology and Toxicology·L Manara, A Bianchetti
May 3, 1980·Lancet
Mar 1, 1959·British Journal of Pharmacology and Chemotherapy·A F GREEN

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Citations

Jan 1, 1997·Peptides·G A OlsonA J Kastin
Dec 16, 1998·Journal of Ethnopharmacology·C S YuanD Liu
May 21, 1998·The American Journal of Chinese Medicine·C S YuanM Gu
Apr 26, 2006·Expert Opinion on Investigational Drugs·Chun-Su Yuan, Robert J Israel
Jan 31, 2016·Journal of Health, Population, and Nutrition·Leo Pruimboom, Karin de Punder
Sep 14, 1999·The American Journal of Physiology·C S YuanZ Q Shi
Feb 20, 2003·Brain Research·Cheng-Shu LiDavid V Smith

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