Gastric emptying and gastro-oesophageal reflux in children with cystic fibrosis

Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society
B HauserY Vandenplas

Abstract

Gastro-oesophageal reflux (GOR) is common in patients with cystic fibrosis (CF). The aim of this study was to investigate the relationship between gastric emptying (GE) and GOR in children with CF. Multichannel intraluminal impedance-pH monitoring (MII-pH) to measure GOR and GE breath test (GEBT) to measure GE were performed in 28 children with symptoms suggestive for GOR disease (GORD) (group 1). GEBT was performed in another 28 children with/without GOR symptoms who agreed to undergo GEBT but not MII-pH (group 2). In group 1, we found increased acid GOR (AGOR) in 46.4% and delayed GE (DGE) in 21.4% but no relationship between increased AGOR and DGE. There was no DGE in group 2. We found DGE in 10.7% and rapid GE in 12.5% of the whole group. Almost half of the children with CF and symptoms suggestive for GORD have increased AGOR and almost a quarter has DGE. However, there was no relation between GOR and GE.

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Citations

Jun 7, 2016·Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society·Steven D Freedman, Sarah Jane Schwarzenberg
May 28, 2019·Minerva pediatrica·Annarita BongiovanniSalvatore Leonardi
Dec 20, 2019·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·Katja KovacicMiguel Saps
Nov 18, 2020·European Journal of Pediatric Surgery : Official Journal of Austrian Association of Pediatric Surgery ... [et Al] = Zeitschrift Für Kinderchirurgie·Jessica NgPaul Charlesworth
Nov 25, 2020·Pediatric Clinics of North America·Emily R Le FevreDominic A Fitzgerald
Nov 28, 2020·World Journal of Gastroenterology : WJG·Annarita BongiovanniSalvatore Leonardi

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