PMID: 11319309Apr 25, 2001Paper

Gastric emptying characteristics of a novel (13)C-octanoate-labeled muffin meal

Journal of Clinical Gastroenterology
W D CheyK Goodman

Abstract

Determine the gastric emptying characteristics of a novel, 350-kcal test meal consisting of two muffins, using scintigraphy and the 13C-octanoate breath test (OBT). Healthy volunteers underwent three studies on separate days within a 1-week period. On day 1, we measured emptying of the 350-kcal muffin test meal labeled simultaneously with 99mTc sulfur colloid and 13C-octanoate. On day 2, reproducibility of the OBT using a single-labeled 350-kcal test meal was assessed. On day 3, the effect of erythromycin on the 350-kcal OBT was determined. The mean (+/-SD) half-emptying time (T1/2) as measured by scintigraphy was 104 +/- 24 minutes, versus 212 +/- 52 minutes by OBT. There was a strong correlation between T1/2 determined by scintigraphy and the breath test (r = 0.83). Multiple linear regression analysis identified a significant relationship between T1/2 determined by scintigraphy and the 90-and 180-minute breath samples. There was a strong correlation (r = 0.830, slope = 0.732 +/- 0.120 [SE], intercept = 26.4 +/- 12.7) between the T1/2 obtained using the regression equation and the actual T1/2 obtained by scintigraphy. The mean T1/2 (+/-SD) for replicate determinations using the OBT was 209 +/- 52 minutes, compared with 196 +/-...Continue Reading

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Citations

Mar 15, 2006·Digestive Diseases and Sciences·Jari PunkkinenJari Koskenpato
Apr 25, 2001·Journal of Clinical Gastroenterology·M Q Bromer, H P Parkman
Apr 29, 2009·The Tohoku Journal of Experimental Medicine·Shiho TeraiTooru Shimosegawa
Jan 1, 2010·Journal of Smooth Muscle Research = Nihon Heikatsukin Gakkai Kikanshi·Masaki Sanaka, Koji Nakada
Jul 25, 2013·Diabetes·Andrea S Shin, Michael Camilleri
Mar 25, 2009·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·S T OdunsiA R Zinsmeister
Apr 25, 2006·Alimentary Pharmacology & Therapeutics·B HauserY Vandenplas
Oct 8, 2003·Journal of Veterinary Internal Medicine·C A WyseP S Yam
Mar 19, 2009·Gastroenterology·Henry P Parkman, Michael P Jones

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