Gastric emptying flow curves separated from carbon-labeled octanoic acid breath test results

The American Journal of Physiology
B MaesP Rutgeerts

Abstract

Recently, we developed the [13/14C]octanoic acid breath test to measure gastric emptying of solids. Although the method has been validated extensively, absorption, metabolism, and excretion of the label in the breath need to be corrected for. In this study a mathematical model was developed that allows for 1) separation of the global CO2 excretion after ingestion of the labeled test meal into the emptying rate of the labeled test meal from mouth to pylorus and the postgastric processing of absorption, metabolism, and excretion of the label, and 2) numerical calculation of the half-emptying time and lag phase of the emptied meal. The model was applied to the gastric emptying results obtained by simultaneous scintigraphic and breath test measurements. An excellent correlation was found between the gastric half-emptying time (r = 0.98) and lag phase (r = 0.85) determined scintigraphically and via breath test. There was also a good agreement between the two methods [mean values and confidence limits for differences: t1/2 = 10 min (-20 to 41) and tlag = -3 min (-39 to 34)]. Moreover, the separated gastric emptying curves, lacking the influence of postgastric processing of the label, showed real patterns of gastric outflow, which cha...Continue Reading

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Citations

May 13, 2005·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Wim LemahieuYves Vanrenterghem
Jul 2, 2009·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·E Qualls-CreekmoreG M Holmes
Jun 12, 2014·Theoretical Biology & Medical Modelling·Shaji KrishnanAlbert A de Graaf
Aug 12, 2003·American Journal of Physiology. Gastrointestinal and Liver Physiology·W P D LemahieuY Vanrenterghem
Apr 29, 2009·The Tohoku Journal of Experimental Medicine·Shiho TeraiTooru Shimosegawa
Jun 6, 2015·American Journal of Physiology. Gastrointestinal and Liver Physiology·Željko BajzerGianrico Farrugia
Oct 7, 2006·Current Opinion in Gastroenterology·E M Quigley
Jan 17, 2009·American Journal of Physiology. Gastrointestinal and Liver Physiology·Lawrence A Szarka, Michael Camilleri

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