PMID: 8583099Dec 1, 1995Paper

Gastric emptying of solids in patients with nonobstructive Crohn's disease is sometimes delayed

Journal of Clinical Gastroenterology
V AnneseA Andriulli

Abstract

To date, only a few studies of gastric emptying in Crohn's disease have been published in the literature. This might be clinically important because slow-release drug formulations are increasingly available for treatment. Studies in children with gastric involvement suggest that gastric emptying may be delayed in this condition. We studied the scintigraphic gastric emptying of 21 adult patients with nonobstructive Crohn's disease and without gastric or duodenal involvement by the disease, compared with that of 20 healthy volunteers. Overall, no significant differences were found, but subgroup analysis showed that symptomatic patients [half-time (t1/2) 133 +/- 75.9] and those with colonic involvement (t1/2 127.2 +/- 64) had a significantly (p < 0.01) delayed gastric emptying over controls (t1/2 85.5 +/- 15.4). Such a difference was also observed between symptomatic and asymptomatic patients (p < 0.05). We conclude that gastric emptying is slowed in symptomatic patients with nonobstructive Crohn's disease and in those with colonic involvement. This may have therapeutic implications.

Citations

Jul 29, 2000·Journal of Clinical Gastroenterology·F CastiglioneG Mazzacca
Dec 12, 2012·BMC Gastroenterology·Ana Carolina Mello NóbregaMarcellus Henrique Loiola Ponte Souza
Mar 23, 2007·BMC Gastroenterology·Jón O KristinssonJoost P H Drenth
Feb 6, 2010·World Journal of Gastroenterology : WJG·Nathalie E RuyssersTom G Moreels
Jan 15, 2014·World Journal of Gastroenterology : WJG·Gabrio BassottiVito Annese
Sep 29, 2001·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·T G MoreelsP A Pelckmans
Jul 6, 2011·Journal of Microencapsulation·Adeola Adebisi, Barbara R Conway
Sep 6, 2006·The Journal of Medical Investigation : JMI·Nao KohnoSusumu Ito
Feb 13, 2001·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·I DepoortereT L Peeters
Oct 1, 2008·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·B De SmetI Depoortere
Jun 25, 2009·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·J KellerM Camilleri
Jul 28, 2005·Chinese Journal of Digestive Diseases·Eamonn M M Quigley
Dec 17, 1997·Scandinavian Journal of Gastroenterology·V AnneseG Vantrappen
Oct 2, 2015·European Journal of Clinical Investigation·Jutta KellerPeter Layer
Nov 10, 2007·American Journal of Physiology. Gastrointestinal and Liver Physiology·H U De SchepperB Y De Winter
Dec 17, 2009·British Journal of Pharmacology·Inge DepoortereJan Tack
Apr 9, 2001·American Journal of Physiology. Gastrointestinal and Liver Physiology·T G MoreelsP A Pelckmans
May 27, 2010·American Journal of Physiology. Gastrointestinal and Liver Physiology·Jutta KellerPeter Layer
Oct 29, 2014·Alimentary Pharmacology & Therapeutics·S FutagamiC Sakamoto
Jun 30, 2016·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·R M McQuadeK Nurgali
Feb 18, 2020·Techniques in Coloproctology·G BassottiG Maconi

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