PMID: 3236214Aug 1, 1988

Gastric emptying rates of drug preparations. I. Effects of size of dosage forms, food and species on gastric emptying rates

Journal of Pharmacobio-dynamics
N KaniwaA Ejima

Abstract

The gastric emptying rates of oral dosage forms of different sizes were studied in humans and beagle dogs measuring of marker drugs such as acetaminophen, aspirin and pyridoxal phosphate in plasma or urine. The marker drugs, except acetaminophen, were contained in enteric-coated granules or tablets which did not dissolve in the stomach but dissolved rapidly in the upper intestine. The gastric emptying rate of a dosage form of smaller size was faster than that of a larger size. The gastric emptying rates of dosage forms with different sizes did not correlate with each other inter-individually. The gastric emptying rates of dosage forms of any size were delayed when drugs were administered after taking a meal. The gastric emptying rates of dosage forms were extremely prolonged in beagle dogs after drug administration postprandially, and this restricted the use of beagle dogs as an animal model in bioavailability tests.

Citations

Sep 1, 1993·British Journal of Clinical Pharmacology·L F PrescottK Sriwatanakul
Jan 22, 2011·Journal of Pharmaceutical Sciences·R Marcus FancherPunit Marathe
Feb 28, 2015·Journal of Pharmaceutical Sciences·Yohei KosugiNobuyuki Amano
Feb 1, 1992·Journal of Pharmaceutical Sciences·Y KawashimaY Itoh
Jul 29, 2008·Journal of Pharmaceutical Sciences·Marilyn N Martinez, Mark G Papich
Jan 17, 2009·Advanced Drug Delivery Reviews·Randall J Mrsny
Jan 18, 2007·The Journal of Pharmacy and Pharmacology·F PodczeckM B Short
Mar 19, 2014·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Erik SjögrenPeter Langguth
Mar 19, 2013·Journal of Controlled Release : Official Journal of the Controlled Release Society·Vipul D PrajapatiBhumi S Zala
Aug 1, 1994·Biopharmaceutics & Drug Disposition·H TakahashiH Shimamura
Aug 20, 2005·Journal of Veterinary Medicine. A, Physiology, Pathology, Clinical Medicine·S SchaerA Steiner
May 9, 2007·Pharmaceutical Development and Technology·Kenneth C Waterman
Aug 21, 2019·Pharmaceutics·Felix SchneiderWerner Weitschies
Apr 3, 2019·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·Masateru MiyakeTadashi Mukai

Related Concepts

Acamol
Zorprin
Canis familiaris
Ingestion
Gastric Emptying
Particle Size
Pyridoxal Phosphate
Enteric Coated Tablet

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