PMID: 590840Oct 1, 1977

Gastric epithelial cell turnover, mucus production, and healing of gastric ulcers with carbenoxolone

W DomschkeD N Croft


Nineteen healthy subjects were studied and 17 patients with gastric ulcer before and after ulcer healing with carbenoxolone. Gastric deoxytibonucleic acid (DNA) loss was measured as an index of epithelial cell turnover, and N-acetylneuraminic acid (NANA) content of gastric juice as an index of mucus secretion. In normal subjects there was a negative correlation (p less that 0-025) between gastric DNA loss and NANA secretion; the lower the cell turnover the higher the NANA production. In gastric ulcer patients DNA loss or turnover was significantly (p less than 0-01) higher than normal, and fell significantly (p less than 0-01) after four weeks' treatment with carbenoxolone when 16 of the 17 ulcers had healed. At the same time NANA output increased significantly (p less than 0-01). It is suggested that patients with gastric ulcer lose cells at a high rate, a state of affairs which is returned towards normal by carbenoxolone, thus allowing the epithelial cells to mature within the mucosa and produce more mucus.


Dec 13, 2000·Phytotherapy Research : PTR·F Borrelli, A A Izzo
Apr 1, 1977·The American Journal of Digestive Diseases·D N Croft
Feb 1, 1986·Digestive Diseases and Sciences·J R MalageladaS C Moore
Jan 1, 1986·Scandinavian Journal of Gastroenterology. Supplement·H R Koelz
Jan 1, 1986·Scandinavian Journal of Gastroenterology. Supplement·J R Malagelada
Jan 1, 1985·Scandinavian Journal of Gastroenterology. Supplement·J Calam
Jun 1, 1985·Scandinavian Journal of Gastroenterology·S J Konturek
Sep 1, 1984·Pharmacological Research Communications·P MinuzG P Velo
Dec 1, 1981·European Journal of Clinical Investigation·W D ReesG Flemström
Dec 1, 1987·Alimentary Pharmacology & Therapeutics·C J Hawkey
Sep 10, 2019·International Journal of Medical Microbiology : IJMM·Prince SharmaRavinder Singh

Related Concepts

DNA, Double-Stranded
Epithelial Cells
Structure of Pyloric Gland
Mucous Body Substance
Sialic Acids
Gastric Ulcer

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Genetic Screens in iPSC-derived Brain Cells

Genetic screening is a critical tool that can be employed to define and understand gene function and interaction. This feed focuses on genetic screens conducted using induced pluripotent stem cell (iPSC)-derived brain cells. It also follows CRISPR-Cas9 approaches to generating genetic mutants as a means of understanding the effect of genetics on phenotype.

Alzheimer's Disease: MS4A

Variants within the membrane-spanning 4-domains subfamily A (MS4A) gene cluster have recently been implicated in Alzheimer's disease in genome-wide association studies. Here is the latest research on Alzheimer's disease and MS4A.

Pediculosis pubis

Pediculosis pubis is a disease caused by a parasitic insect known as Pthirus pubis, which infests human pubic hair, as well as other areas with hair including eye lashes. Here is the latest research.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Rh Isoimmunization

Rh isoimmunization is a potentially preventable condition that occasionally is associated with significant perinatal morbidity or mortality. Discover the latest research on Rh Isoimmunization here.

Pharmacology of Proteinopathies

This feed focuses on the pharmacology of proteinopathies - diseases in which proteins abnormally aggregate (i.e. Alzheimer’s, Parkinson’s, etc.). Discover the latest research in this field with this feed.

Enzyme Evolution

This feed focuses on molecular models of enzyme evolution and new approaches (such as adaptive laboratory evolution) to metabolic engineering of microorganisms. Here is the latest research.

Alignment-free Sequence Analysis Tools

Alignment-free sequence analyses have been applied to problems ranging from whole-genome phylogeny to the classification of protein families, identification of horizontally transferred genes, and detection of recombined sequences. Here is the latest research.