PMID: 590840Oct 1, 1977

Gastric epithelial cell turnover, mucus production, and healing of gastric ulcers with carbenoxolone

Gut
W DomschkeD N Croft

Abstract

Nineteen healthy subjects were studied and 17 patients with gastric ulcer before and after ulcer healing with carbenoxolone. Gastric deoxytibonucleic acid (DNA) loss was measured as an index of epithelial cell turnover, and N-acetylneuraminic acid (NANA) content of gastric juice as an index of mucus secretion. In normal subjects there was a negative correlation (p less that 0-025) between gastric DNA loss and NANA secretion; the lower the cell turnover the higher the NANA production. In gastric ulcer patients DNA loss or turnover was significantly (p less than 0-01) higher than normal, and fell significantly (p less than 0-01) after four weeks' treatment with carbenoxolone when 16 of the 17 ulcers had healed. At the same time NANA output increased significantly (p less than 0-01). It is suggested that patients with gastric ulcer lose cells at a high rate, a state of affairs which is returned towards normal by carbenoxolone, thus allowing the epithelial cells to mature within the mucosa and produce more mucus.

Citations

Dec 13, 2000·Phytotherapy Research : PTR·F Borrelli, A A Izzo
Apr 1, 1977·The American Journal of Digestive Diseases·D N Croft
Feb 1, 1986·Digestive Diseases and Sciences·J R MalageladaS C Moore
Jan 1, 1986·Scandinavian Journal of Gastroenterology. Supplement·H R Koelz
Jan 1, 1986·Scandinavian Journal of Gastroenterology. Supplement·J R Malagelada
Jan 1, 1985·Scandinavian Journal of Gastroenterology. Supplement·J Calam
Jun 1, 1985·Scandinavian Journal of Gastroenterology·S J Konturek
Sep 1, 1984·Pharmacological Research Communications·P MinuzG P Velo
Dec 1, 1981·European Journal of Clinical Investigation·W D ReesG Flemström
Dec 1, 1987·Alimentary Pharmacology & Therapeutics·C J Hawkey
Sep 10, 2019·International Journal of Medical Microbiology : IJMM·Prince SharmaRavinder Singh

Related Concepts

Pharmaxolon
DNA, Double-Stranded
Epithelial Cells
Structure of Pyloric Gland
Mucous Body Substance
Sialic Acids
Gastric Ulcer
Triterpenes

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