Gastric foveolar metaplasia and gastric heterotopia in the duodenum: no evidence of an etiologic role for Helicobacter pylori

Human Pathology
R M GentaSmita Suterwala

Abstract

Gastric-type epithelium and islands of oxyntic mucosa in duodenal biopsies are considered by some to be part of a spectrum of metaplastic change related to peptic disorders. This study was designed to assess prevalence and associations of metaplastic-heterotopic gastric mucosa in the duodenum. Demographic, clinical, and histopathologic data from patients who had duodenal biopsy specimens for a 12-month period were collected from a national database. The duodenal findings of patients with duodenitis, gastric metaplasia, and gastric heterotopia were correlated with gastric pathology, Helicobacter pylori status, and clinical information. Of 28,210 patients with duodenal biopsy specimens, 80.9% were healthy, 2.1% had active duodenitis, 2.2% gastric foveolar metaplasia without active inflammation ("peptic duodenopathy"), 4.8% gastric foveolar metaplasia with active inflammation ("peptic duodenitis"), and 1.9% gastric heterotopia. Helicobacter pylori was documented in 9.8% of patients with normal duodenum, 6.9% of those with gastric metaplasia without active inflammation, 15.8% of those with active duodenitis, and 29.1% of those with gastric foveolar metaplasia with active inflammation; 2.2% of 543 patients with gastric heterotopia h...Continue Reading

References

Aug 21, 1976·British Medical Journal·O A Husain, J M Grainger
Dec 1, 1990·Journal of Clinical Pathology·J I WyattM F Dixon
Jan 1, 1989·Scandinavian Journal of Gastroenterology. Supplement·J I Wyatt
Jan 1, 1970·Digestion·P J Hoedemaeker
May 1, 1983·Gastrointestinal Endoscopy·F J VizcarrondoP G Brady
Jun 1, 1982·Journal of Clinical Pathology·A M Lessells, D F Martin
Dec 1, 1996·Human Pathology·H M El-ZimaityD Y Graham
Sep 2, 1998·Journal of Advanced Nursing·D A Lowry
Sep 27, 2001·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·M HeikkinenR Julkunen
Aug 1, 1964·Gut·A H JAMES
Mar 27, 2004·The American Journal of Surgical Pathology·Barbara TriblAndreas Chott
Aug 31, 2006·Seminars in Diagnostic Pathology·Robert M Genta
Mar 27, 2007·Best Practice & Research. Clinical Gastroenterology·Hoda M Malaty
Mar 7, 2008·World Journal of Gastroenterology : WJG·Hugh-James Freeman
Nov 14, 2008·Current Gastroenterology Reports·David Y Graham, Robert M Genta
May 26, 2009·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Robert M GentaRichard H Lash

❮ Previous
Next ❯

Citations

May 24, 2011·Journal of Neurogastroenterology and Motility·Hidekazu SuzukiToshifumi Hibi
Oct 15, 2013·American Journal of Epidemiology·Benjamin LebwohlRobert M Genta
Aug 30, 2012·Alimentary Pharmacology & Therapeutics·I MaguilnikR M Genta
Apr 1, 2015·Gastroenterology·Han-Jung LinMing-Jen Chen
Dec 5, 2012·Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society·Ana Flávia Passos RamosLuiz Gonzaga Vaz Coelho
May 24, 2011·Gastrointestinal Endoscopy·Benjamin LebwohlRobert M Genta
Aug 12, 2014·Digestive Diseases and Sciences·Seyed Sina MirbagheriHoda Safa
Feb 26, 2016·Journal of Pediatric Gastroenterology and Nutrition·Josef SýkoraJan Schwarz
Oct 21, 2016·Arquivos Brasileiros De Cirurgia Digestiva : ABCD = Brazilian Archives of Digestive Surgery·Irma Cláudia Saboya RibeiroAline Neppel
Apr 30, 2013·The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi·Ji-Hyun SeoJeong Hee Lee
Oct 4, 2014·Journal of Clinical Laboratory Analysis·Souvik GhatakNachimuthu Senthil Kumar
Oct 17, 2019·Journal of Gastroenterology and Hepatology·Masaki TakinamiHiroyuki Ono
May 18, 2016·World Journal of Gastroenterology : WJG·Roberto Herrera-GoepfertRodrigo González-Barrios
Jun 29, 2017·Case Reports in Gastrointestinal Medicine·Majd AlfrejatJennifer Eschbacher
Sep 17, 2020·Journal of Clinical Pathology·Adam L Booth, Raul S Gonzalez
Jun 28, 2014·Virchows Archiv : an International Journal of Pathology·Miku NakagawaSohei Kitazawa
Feb 9, 2021·JGH Open : an Open Access Journal of Gastroenterology and Hepatology·Takayoshi KibaMasahiro Tsuboi
Aug 26, 2021·Clinical Case Reports·Francesco MaioneGiovanni Domenico De Palma

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anemia

Anemia develops when your blood lacks enough healthy red blood cells. Anemia of inflammation (AI, also called anemia of chronic disease) is a common, typically normocytic, normochromic anemia that is caused by an underlying inflammatory disease. Here is the latest research on anemia.

Anxiety Disorders

Discover the latest research on anxiety disorders including agoraphobia, panic disorder, obsessive-compulsive disorder, and post-traumatic stress disorder here.

Atrophic Gastritis

Atrophic Gastritis is a process where gastric glandular cells are lost and replaced with firbous tissues, as a result of chronic inflammation. Learn more about Atrophic Gastritis here.

Related Papers

Journal of Clinical Gastroenterology
N S MannE Rachut
Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association
R M GentaRichard H Lash
Mayo Clinic Proceedings
N J TalleyS F Phillips
Journal of Gastroenterology and Hepatology
Y Urakami, T Sano
© 2021 Meta ULC. All rights reserved