Gastric foveolar metaplasia with dysplastic changes in Brunner gland hyperplasia: possible precursor lesions for Brunner gland adenocarcinoma

The American Journal of Surgical Pathology
Takaki SakuraiToshiaki Manabe

Abstract

Cases of adenocarcinomas developed in Brunner gland hyperplasia (BGH) have been sporadically reported. Herein, we report the morphologic spectrum of hyperplastic changes culminating into dysplasia and carcinoma in 722 cases of BGH listed in our files. Fifteen of these cases showed dysplastic changes, with 8 graded as low-grade dysplasia, 5 as high-grade dysplasia, 11 as atypical hyperplasia, and 2 as invasive carcinoma, although each frequently coexisted in the same tumor. In two carcinomas, one had high-grade dysplasia in the mucosa, and another had only atypical hyperplasia. Interestingly, hyperplastic glands around dysplastic foci were associated with gastric foveolar metaplasia and papillary configuration in 13 cases, 11 of which showed a gradual increase in nuclear atypism in the transition from metaplastic to dysplastic glands. All of the metaplastic gastric glands showed diffuse and strong immunopositivity for gastric foveolar mucin (MUC5AC). Immunohistochemical profiles also supported the concept of a continuous spectrum in carcinogenesis from gastric foveolar hyperplasia through atypical hyperplasia or dysplasia and eventually to frank adenocarcinoma. The results of our study suggest, therefore, that dysplastic and/or ...Continue Reading

References

Oct 1, 1990·Journal of Surgical Oncology·H MatsuuraY Haraguchi
Dec 1, 1990·Journal of Clinical Pathology·J I WyattM F Dixon
Feb 1, 1990·Scandinavian Journal of Gastroenterology·Y FuseK Kashima
Mar 1, 1970·Archives of Surgery·W H ReMineE G Harrison
Jul 15, 1994·Cancer·G N Stemmermann
Feb 1, 1993·Gastroenterologia Japonica·M ItsunoH Watanabe
Oct 1, 1996·The Journal of Pathology·T TeradaY S Kim
Feb 19, 2000·Journal of Gastroenterology·E FujimakiY Takeda
Dec 2, 2000·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·M P BuisineN Porchet
Apr 25, 2001·Journal of Clinical Gastroenterology·D YadavC S Pitchumoni
May 8, 2002·Journal of Gastroenterology·Kimishige AkinoKohzoh Imai

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Citations

Jul 14, 2006·Journal of Clinical Pathology·C A Rubio
Jul 28, 2012·Digestive Diseases and Sciences·Kyungeun KimEunsil Yu
Jun 9, 2009·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Koji KitagoriTakaki Sakurai
Jul 19, 2016·Acta chirurgica Belgica·Lisa SantyLieven Dedrye
Feb 17, 2017·Case Reports in Gastroenterology·Michele SorletoCarsten Gartung
Sep 11, 2012·Veterinary Pathology·T J Steinbach, J D Kane
Mar 24, 2017·ACG Case Reports Journal·Manraj KhoslaAnanya Das
Jan 30, 2019·Pathology International·Tomoko UchiyamaChiho Ohbayashi
Oct 26, 2018·Archives of Pathology & Laboratory Medicine·Katrina Collins, Saverio Ligato
Oct 14, 2014·The American Journal of Surgical Pathology·Tetsuo UshikuGregory Y Lauwers
Apr 2, 2014·Clinical Nuclear Medicine·Seol Hoon ParkJae Seung Kim
Jun 13, 2019·Canadian Journal of Gastroenterology & Hepatology·Sabahattin Destek, Vahit Onur Gul
Apr 2, 2018·Clinical Journal of Gastroenterology·Yasumasa MatsuoFumio Itoh
Mar 17, 2017·Case Reports in Surgery·Nicola C FrenkelJeroen Hagendoorn
Apr 6, 2021·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Riccardo CarboneAntonio Di Sabatino
May 1, 2021·International Journal of Molecular Sciences·Alessandro VanoliAntonio Di Sabatino
Apr 30, 2021·Advances in Therapy·Menghua ZhuXingshun Qi

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