Gastric foveolar metaplasia with dysplastic changes in Brunner gland hyperplasia: possible precursor lesions for Brunner gland adenocarcinoma

The American Journal of Surgical Pathology
Takaki SakuraiToshiaki Manabe


Cases of adenocarcinomas developed in Brunner gland hyperplasia (BGH) have been sporadically reported. Herein, we report the morphologic spectrum of hyperplastic changes culminating into dysplasia and carcinoma in 722 cases of BGH listed in our files. Fifteen of these cases showed dysplastic changes, with 8 graded as low-grade dysplasia, 5 as high-grade dysplasia, 11 as atypical hyperplasia, and 2 as invasive carcinoma, although each frequently coexisted in the same tumor. In two carcinomas, one had high-grade dysplasia in the mucosa, and another had only atypical hyperplasia. Interestingly, hyperplastic glands around dysplastic foci were associated with gastric foveolar metaplasia and papillary configuration in 13 cases, 11 of which showed a gradual increase in nuclear atypism in the transition from metaplastic to dysplastic glands. All of the metaplastic gastric glands showed diffuse and strong immunopositivity for gastric foveolar mucin (MUC5AC). Immunohistochemical profiles also supported the concept of a continuous spectrum in carcinogenesis from gastric foveolar hyperplasia through atypical hyperplasia or dysplasia and eventually to frank adenocarcinoma. The results of our study suggest, therefore, that dysplastic and/or ...Continue Reading


Oct 1, 1990·Journal of Surgical Oncology·H MatsuuraY Haraguchi
Dec 1, 1990·Journal of Clinical Pathology·J I WyattM F Dixon
Feb 1, 1990·Scandinavian Journal of Gastroenterology·Y FuseK Kashima
Mar 1, 1970·Archives of Surgery·W H ReMineE G Harrison
Jul 15, 1994·Cancer·G N Stemmermann
Feb 1, 1993·Gastroenterologia Japonica·M ItsunoH Watanabe
Oct 1, 1996·The Journal of Pathology·T TeradaY S Kim
Feb 19, 2000·Journal of Gastroenterology·E FujimakiY Takeda
Dec 2, 2000·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·M P BuisineN Porchet
Apr 25, 2001·Journal of Clinical Gastroenterology·D YadavC S Pitchumoni
May 8, 2002·Journal of Gastroenterology·Kimishige AkinoKohzoh Imai

❮ Previous
Next ❯


Jul 14, 2006·Journal of Clinical Pathology·C A Rubio
Jul 28, 2012·Digestive Diseases and Sciences·Kyungeun KimEunsil Yu
Jun 9, 2009·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Koji KitagoriTakaki Sakurai
Jul 19, 2016·Acta chirurgica Belgica·Lisa SantyLieven Dedrye
Feb 17, 2017·Case Reports in Gastroenterology·Michele SorletoCarsten Gartung
Sep 11, 2012·Veterinary Pathology·T J Steinbach, J D Kane
Mar 24, 2017·ACG Case Reports Journal·Manraj KhoslaAnanya Das
Jan 30, 2019·Pathology International·Tomoko UchiyamaChiho Ohbayashi
Oct 26, 2018·Archives of Pathology & Laboratory Medicine·Katrina Collins, Saverio Ligato
Oct 14, 2014·The American Journal of Surgical Pathology·Tetsuo UshikuGregory Y Lauwers
Apr 2, 2014·Clinical Nuclear Medicine·Seol Hoon ParkJae Seung Kim
Jun 13, 2019·Canadian Journal of Gastroenterology & Hepatology·Sabahattin Destek, Vahit Onur Gul
Apr 2, 2018·Clinical Journal of Gastroenterology·Yasumasa MatsuoFumio Itoh
Mar 17, 2017·Case Reports in Surgery·Nicola C FrenkelJeroen Hagendoorn
Apr 6, 2021·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Riccardo CarboneAntonio Di Sabatino
May 1, 2021·International Journal of Molecular Sciences·Alessandro VanoliAntonio Di Sabatino
Apr 30, 2021·Advances in Therapy·Menghua ZhuXingshun Qi

❮ Previous
Next ❯

Related Concepts

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Epigenetics Insights from Twin Studies

Find the latest research on epigenetics and twin studies here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.


Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Regulation of Vocal-Motor Plasticity

Dopaminergic projections to the basal ganglia and nucleus accumbens shape the learning and plasticity of motivated behaviors across species including the regulation of vocal-motor plasticity and performance in songbirds. Discover the latest research on the regulation of vocal-motor plasticity here.

Myocardial Stunning

Myocardial stunning is a mechanical dysfunction that persists after reperfusion of previously ischemic tissue in the absence of irreversible damage including myocardial necrosis. Here is the latest research.