PMID: 9298880Sep 23, 1997

Gastric graft-versus-host disease: a blinded histologic study

The American Journal of Surgical Pathology
Kay WashingtonH R Krigman

Abstract

Acute graft-versus-host disease (GvHD) of the upper gastrointestinal (GI) tract is common after allogeneic bone marrow transplantation (BMT). However, diagnosis cannot be made on clinical presentation and endoscopic findings alone, because these are nonspecific, and histologic confirmation is often desirable. The diagnosis of gastric GvHD is often based on subtle findings with considerable potential for variability in interpretation. Evaluation of the reproducibility of diagnosis and recognition of histologic features of gastric GvHD was based on blinded review of 56 gastric biopsies (24 from patients with allogeneic BMT or unrelated umbilical cord blood transplantation and 32 control biopsies from patients who did not undergo BMT, of whom eight had active GI cytomegalovirus [CMV] infection). Histologic criteria for GvHD were apoptosis and gland destruction, sparse inflammatory infiltrate, and granular eosinophilic debris in dilated glands. Seventeen patients (22 biopsies) were judged to have clinical GvHD on the basis of skin or liver involvement and GI symptoms without other known cause. Eighteen of these 22 gastric biopsies were classified as GvHD by at least two of the three pathologists on initial review. Blinded histologi...Continue Reading

References

Nov 5, 2004·Annals of Hematology·C GörgA Neubauer
Feb 1, 2011·Der Pathologe·F LängerH Kreipe
Mar 25, 2000·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Y UenoS Nagata
Sep 17, 2004·The American Journal of Surgical Pathology·Wei Xin, Joel Greenson
Nov 13, 2004·American Journal of Clinical Pathology·Su-Peng YehChang-Fang Chiu
Oct 1, 2013·Bone Marrow Transplantation·C Bodet-MilinMohamad Mohty
Apr 16, 2014·Mediators of Inflammation·Florent Malard, Mohamad Mohty
Dec 8, 2009·Journal of Gastroenterology·Gregory Y LauwersMichio Shimizu
Jun 16, 2009·Human Pathology·Kay Washington, Madan Jagasia
Feb 14, 2007·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Marian M Haber
Aug 23, 2006·Gastrointestinal Endoscopy·Khalid KhanRajaram Nagarajan
Aug 23, 2006·Gastrointestinal Endoscopy·William Berquist, Christopher C Dvorak
Jan 6, 2007·Histopathology·A Srivastava, Gregory Y Lauwers
Sep 10, 2014·Histopathology·Newton A C S Wong
Jul 15, 2015·Virchows Archiv : an International Journal of Pathology·Andreas KreftGastrointestinal Pathology Group of the German-Austrian-Swiss GvHD Consortium
Jan 10, 2006·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Howard M ShulmanGeorgia B Vogelsang
Jan 31, 2006·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Leona HolmbergGeorge B McDonald
Mar 10, 2001·The American Journal of Gastroenterology·J M SchwartzGeorge B McDonald
Nov 15, 2003·International Journal of Surgical Pathology·John C PapadimitriouCinthia B Drachenberg
Mar 4, 2000·Microscopy Research and Technique·A von Herbay, J Rudi
Nov 24, 2017·Virchows Archiv : an International Journal of Pathology·Fanny SauvestreMarion Marty
Jul 15, 2003·Bone Marrow Transplantation·T YoshimasuK Tsuji
Nov 30, 2000·The American Journal of Gastroenterology·N IqbalC M Wilcox
Jun 16, 2007·American Journal of Hematology·Joshua MelsonAli Keshavarzian
May 16, 2014·Transplantation·Julie AbrahamGerard Socie
Oct 8, 1999·Journal of Pediatric Gastroenterology and Nutrition·R DohilJ Dimmick
Dec 21, 2019·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Mohamed MostafaCatherine E Hagen
Apr 25, 2003·American Journal of Clinical Pathology·H Evin GulbahceJose Jessurun
Dec 7, 2017·International Journal of Surgical Pathology·Belinda L SunAchyut K Bhattacharyya
Sep 27, 2018·Virchows Archiv : an International Journal of Pathology·Hala El-ZimaityRobert Riddell

Citations

Aug 1, 1979·The American Journal of Surgical Pathology·G E SaleE D Thomas
May 1, 1988·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Howard M ShulmanGeorge B McDonald
Jan 1, 1984·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·D SnoverJ H Kersey
Oct 1, 1984·Annals of Internal Medicine·D P KotlerP R Holt
Jun 1, 1982·The American Journal of Surgical Pathology·B B GallucciE D Thomas
Jun 1, 1995·American Journal of Clinical Pathology·J A BombíA Cardesa
Aug 1, 1994·American Journal of Clinical Pathology·D P MarmadukeJ F Cornhill

Related Concepts

Endoscopy (Procedure)
Primary Immune Deficiency Disorder
Immunologic Deficiency Syndromes
Apoptosis, Intrinsic Pathway
Acute GVH Disease
Graft-vs-Host Disease
Bone Marrow
HIV Infections
Kidney
Graft-Versus-Host Disease Pathway

Related Feeds

Allogenic & Autologous Therapies

Allogenic therapies are generated in large batches from unrelated donor tissues such as bone marrow. In contrast, autologous therapies are manufactures as a single lot from the patient being treated. Here is the latest research on allogenic and autologous therapies.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.

Atrophic Gastritis

Atrophic Gastritis is a process where gastric glandular cells are lost and replaced with firbous tissues, as a result of chronic inflammation. Learn more about Atrophic Gastritis here.