Gastric hypersensitivity induced by oesophageal acid infusion in healthy volunteers

Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society
Bram D van den ElzenG E Boeckxstaens

Abstract

Distal oesophageal acid exposure has been shown to increase visceral sensitivity of the proximal oesophagus via central sensitization. Here we evaluated whether acidification of the distal oesophagus also affects the sensorimotor function of the proximal stomach. A gastric barostat study combined with a 30-min acid (HCl 0.15 mol L(-1)) or saline infusion in the distal oesophagus was performed in 18 healthy volunteers. Gastric and cutaneous sensitivity was assessed before and up to 2 h after the start of infusion. Directly after acid infusion, but not after saline, the threshold for discomfort decreased (-6.4 +/- 1.7 vs 0.4 +/- 0.4 mmHg; P = 0.028) and distension-induced symptoms increased significantly compared with the baseline (122 +/- 49% vs -3 +/- 9%). Cutaneous sensitivity remained unaffected by acid infusion. In contrast, when the infused liquid was aspirated 3 cm more distally, at the level of the lower oesophageal sphincter, the effect of acid infusion on gastric sensitivity was abolished and the increase in distension-induced symptoms was reduced (61 +/- 24%). Distal oesophageal acid infusion induces visceral hypersensitivity without affecting somatic sensitivity arguing against a similar mechanism of central sensitiza...Continue Reading

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Nov 1, 2012·World Journal of Gastroenterology : WJG·Akihito IidaKunio Kasugai
May 9, 2009·Basic & Clinical Pharmacology & Toxicology·Anne Estrup OlesenAsbjørn Mohr Drewes
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