PMID: 7010526Jan 1, 1980Paper

Gastric inhibitory polypeptide (GIP) and insulin release after small-bowel resection in man

Scandinavian Journal of Gastroenterology
K B LauritsenS Lindkaer Jensen

Abstract

Fifteen patients in whom various parts of the small intestine had been resected because of Crohn's disease or mesenteric thrombosis and 10 healthy volunteers were studied. A 50-g oral glucose load (OGTT) and an intravenous glucose infusion giving the same plasma glucose profile as the OGTT were carried out to study (a) the relation between the plasma gastric inhibitory polypeptide (GIP) levels after oral glucose and the length and nature of the intestinal residues and (b) the importance of endogenous GIP as an incretin in man. The magnitude of the increase in plasma GIP after oral glucose load was positively correlated to the length of residual jejunum. The incretin effect was positively correlated to the length of residual intestine. Patients with preserved ileal residues had larger incretin effects than patients with less than 150 cm jejunal residues and no ileal residues, although the integrated increases in plasma GIP after oral glucose were equal. Compared with healthy volunteers, the patients with more than 150 cm residual jejunum had significantly higher increases in plasma GIP and normal incretin effects. The GIP release and the incretin effect in patients with preserved ileal residues were normal. The incretin effect o...Continue Reading

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Citations

Jul 1, 1992·Diabetes/metabolism Reviews·W Creutzfeldt, M Nauck
Apr 1, 1985·World Journal of Surgery·C RicourC Nihoul-Fekete
Jan 1, 1994·Baillière's Clinical Endocrinology and Metabolism·J J Holst, P Schmidt
Jan 2, 2007·Southern Medical Journal·Nasser Mikhail
Mar 1, 1981·Acta Physiologica Scandinavica·S L JensenK B Lauritsen
Jun 6, 2012·Experimental Diabetes Research·Francis S Willard, Kyle W Sloop
Jan 21, 2012·The Review of Diabetic Studies : RDS·Cendrine Cabou, Rémy Burcelin
May 15, 2007·Gastroenterology·Laurie L Baggio, Daniel J Drucker
Feb 1, 2007·Diabetic Medicine : a Journal of the British Diabetic Association·J F Todd, S R Bloom
Apr 4, 2016·Trends in Molecular Medicine·Brian FinanMatthias H Tschöp
Jun 1, 1985·Clinical Biochemistry·V Marks
Feb 18, 2004·Diabetologia·T Vilsbøll, J J Holst
Jul 24, 2004·American Journal of Physiology. Endocrinology and Metabolism·Jens Juul Holst, Jesper Gromada
Dec 22, 1999·Endocrine Reviews·T J Kieffer, J F Habener
Jan 1, 1983·Scandinavian Journal of Gastroenterology·O Flaten
Mar 1, 1982·Scandinavian Journal of Gastroenterology·K B LauritsenK C Christensen
Apr 1, 1981·Scandinavian Journal of Gastroenterology·B LauritsenA J Moody
May 14, 2019·Frontiers in Endocrinology·Jens Juul Holst
Jul 23, 2020·Nature Metabolism·Glyn M Noguchi, Mark O Huising
Nov 27, 2019·Molecular Metabolism·T D MüllerM H Tschöp
Mar 31, 2021·Endocrinology·Jens Juul HolstMette Marie Rosenkilde

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