PMID: 9165412Jun 1, 1997Paper

Gastric intramucosal pH changes after volume replacement with hydroxyethyl starch or crystalloid in patients undergoing elective abdominal aortic aneurysm repair

Journal of Critical Care
P E MarikB Maini

Abstract

Gastric intramucosal pH (pHi), a surrogate marker of tissue oxygenation, falls following abdominal aorta aneurysm (AAA) repair. We tested the hypothesis that volume replacement with a hydroxyethyl starch solution would result in better preserved splanchnic oxygenation than would volume replacement with crystalloid solutions. This was a prospective, randomized, nonblinded study set in a university-affiliated community hospital. Thirty patients undergoing elective AAA repair were studied. Patients were randomly selected to receive intraoperative and postoperative fluid replacement with either hetastarch or crystalloid. According to the study protocol, patients could not receive in excess of 3,000 mL of hetastarch. Tissue oxygenation was assessed indirectly by measuring pHi using a nasogastric tonometer. Hemodynamic, oxygenation, and pHi data were collected preoperatively, preclamp, before unclamping, at the end of the procedure and postoperatively for 24 hours. Coagulation parameters were determined preoperatively and postoperatively for 24 hours. Fifteen patients were randomized to each group. There were 18 male and 12 female patients, whose mean age was 66 +/- 9 years. The intraoperative fluid balance was significantly greater ...Continue Reading

References

Jun 1, 1992·Critical Care Medicine·R C BoneW J Sibbald
May 1, 1988·Journal of Clinical Pharmacology·J L FalkM H Weil
Apr 1, 1971·The American Journal of Cardiology·W GanzH J Swan
May 1, 1995·British Journal of Anaesthesia·R G Fiddian-Green

❮ Previous
Next ❯

Citations

Mar 3, 2011·European Journal of Clinical Pharmacology·Xue-Yin ShiHu Liu
Mar 13, 2002·Cardiovascular Surgery : Official Journal of the International Society for Cardiovascular Surgery·D RittooR K Vohra
Oct 3, 1999·Critical Care Medicine·M Mythen
Sep 24, 2009·Critical Care Medicine·Lena M NapolitanoUNKNOWN Eastern Association for the Surgery of Trauma Practice Management Workgroup
Nov 26, 2004·American Journal of Respiratory and Critical Care Medicine·UNKNOWN American Thoracic Society
Apr 25, 2001·Journal of the American Veterinary Medical Association·P A JonesR C Boston
Jun 23, 2006·Intensive Care Medicine·Joanne VerheijA B Johan Groeneveld
Aug 26, 2006·AACN Advanced Critical Care·Cindy Goodrich
Nov 2, 2006·Transfusion·Alan TinmouthUNKNOWN Canadian Critical Care Trials Group
Oct 20, 2001·Disease-a-month : DM·P E Marik, J Varon
Dec 9, 2008·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·A MahmoodR Vohra
Sep 23, 2014·Journal of Cardiothoracic and Vascular Anesthesia·Hans KnotzerAxel Kleinsasser
Jan 8, 2015·Anesthesia and Analgesia·Diego Orbegozo CortésJean-Louis Vincent
Sep 25, 2008·Anesthesiology·Daniel ChappellMarkus Rehm
May 26, 2016·Journal of Cardiothoracic and Vascular Anesthesia·Robert S GreenMete Erdogan
Jan 22, 2010·The Cochrane Database of Systematic Reviews·Patiparn Toomtong, Sirilak Suksompong
Sep 16, 2010·Anesthesia and Analgesia·João M P BarrosJosé R C Braz
Aug 25, 2020·Critical Care Research and Practice·Seechad Noonpradej, Osaree Akaraborworn
May 29, 2001·Anesthesia and Analgesia·A FranzS A Kozek-Langenecker
Sep 10, 2015·European Journal of Anaesthesiology·Mohamed RaimanReitze N Rodseth
Jun 1, 2006·Journal of the American College of Surgeons·Kathrine Holte, Henrik Kehlet

❮ Previous
Next ❯

Related Concepts

Related Feeds

Aortic Aneurysm

An aortic aneurysm is the weakening and bulging of the blood vessel wall in the aorta. This causes dilatation of the aorta, which is usually asymptomatic but carries the risk of rupture and hemorrhage. Find the latest research on aortic aneurysms here.

Blood Clotting Disorders

Thrombophilia includes conditions with increased tendency for excessive blood clotting. Blood clotting occurs when the body has insufficient amounts of specialized proteins that make blood clot and stop bleeding. Here is the latest research on blood clotting disorders.

Aneurysm

Aneurysms are outward distensions or bulges that occurs in a weakened wall of blood vessels. Discover the latest research on aneurysms here.