PMID: 6172674Jan 1, 1981Paper

Gastric leiomyosarcoma: clinical and pathological review of fifty patients

Journal of Surgical Oncology
P C LindsayJ H Raaf

Abstract

Fifty patients with gastric leiomyosarcoma seen at M.D. Anderson Hospital between 1957 and 1978 were reviewed. Symptoms included weakness, gastrointestinal bleeding, and epigastric pain. An upper abdominal mass or tenderness was the most frequent physical finding. Laparotomy was performed in all patients, with gastric resection in 86%, and resection for cure in 68%. Survival after distal subtotal gastric resection (mean: 62 months) was longer than after proximal subtotal (30 months) or wedge resection (46 months). The five-year survival was 19% for all patients, and 32% for those operated on for cure. A favorable prognosis was predicted by mild atypia or few mitoses (grade 1). No differences in survival were demonstrated between patients with tumors of different cell types (epithelioid, spindle, or pleomorphic). No lymph node in any patient contained metastatic tumor, suggesting a lymph node dissection need not be performed. Commonly, tumor spread was to liver or lungs or by direct invasion of contiguous tissue or organ. Radiotherapy and chemotherapy are of limited value in treating unresectable disease. If possible, both the primary lesion and recurrent tumor should be widely resected.

References

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Citations

Dec 12, 2012·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Sabha GanaiKevin K Roggin
Jun 12, 2002·Current Treatment Options in Oncology·C D BlankeM C Heinrich
Jul 2, 2003·Molecular Immunology·Walid SalamounDany Abi Gerges
Apr 24, 1999·The British Journal of Surgery·D LevM Gutman
Sep 13, 2001·ANZ Journal of Surgery·S R DubenecP G Truskett
Jun 1, 1987·Annals of Surgery·R B AdkinsJ L Sawyers
Dec 1, 1987·Annals of Surgery·P C McGrathG A Parker
Aug 1, 1990·The Australian and New Zealand Journal of Surgery·S Choen, A Rauff
Jun 1, 1991·Postgraduate Medical Journal·R FlynnT M Feeley
May 1, 1987·The Australian and New Zealand Journal of Surgery·S SenewiratneP G Reasbeck
Dec 28, 2004·The Surgical Clinics of North America·Seigo Kitano, Norio Shiraishi
Jul 31, 2004·World Journal of Gastroenterology : WJG·Chi-Ming LeeYa-Yen Chen
Nov 10, 2011·Journal of Surgical Oncology·Henry D Appelman
Jun 1, 1991·Postgraduate Medical Journal·M L Ong
May 17, 2005·Journal of Surgical Oncology·Michael C Heinrich, Christopher L Corless
May 1, 1994·Annals of Surgical Oncology·W CarsonM L Palmer
Mar 31, 2000·Journal of the Royal Society of Medicine·L S WongT Ismail
Jan 1, 1995·Annals of Surgical Oncology·K C ConlonM F Brennan
Apr 1, 1989·Scottish Medical Journal·U G Fazzi, D T Hansell
Oct 18, 2000·Archives of Pathology & Laboratory Medicine·L WangS W French

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