Gastric lipase in alcoholic pancreatitis. Comparison of secretive profiles following pentagastrin stimulation in normal adults and patients with pancreatic insufficiency

Gastroenterology
J MoreauA Ribet

Abstract

The aims of this study were to evaluate the amount of gastric lipase secreted by the stomach in normal adults and to elucidate a possible adaptative secretion of this enzyme in response to pancreatic insufficiency secondary to alcoholic chronic pancreatitis. Forty-one subjects underwent a gastric intubation. Pentagastrin (6 micrograms.kg-1.h-1 IV) significantly increased gastric lipase concentration and output. Stimulated gastric lipase output in seven normal subjects was 12,598 +/- 2036 U/h (by using tributyrin as substrate). Outputs where higher (P less than 0.02) in 17 patients with pancreatic insufficiency who were not drinking alcohol, but were not significantly different in nine patients who continued to drink (20,413 +/- 1778 U/h and 21,953 +/- 4973 U/h, respectively). On the other hand, high gastric lipase outputs were found in eight patients with duodenal ulcers and no evidence of pancreatic dysfunction (23,180 +/- 262 U/h). The time required to reach maximal lipase output (peak output) following pentagastrin stimulation was the same in all groups (approximately 38 minutes) except for the group of patients with pancreatic insufficiency who did not drink alcohol, in whom it was significantly reduced (approximately 26.5 ...Continue Reading

Citations

Jan 1, 1995·JPEN. Journal of Parenteral and Enteral Nutrition·M LedeboerC B Lamers
Mar 2, 2006·Digestive Diseases·Roland H Pfutzer, Alexander Schneider
Jul 1, 1995·Scandinavian Journal of Gastroenterology·M WøjdemannO Olsen
Jan 1, 1993·Archives Internationales De Physiologie, De Biochimie Et De Biophysique·M Descroix-VagneH Rakotomalala
Mar 1, 1997·Scandinavian Journal of Gastroenterology·M WøjdemannJ F Rehfeld
Jul 27, 2012·Therapeutic Delivery·Jean-Claude Bakala N'GomaFrédéric Carrière
Mar 17, 2000·Scandinavian Journal of Gastroenterology·M WøjdemannO Olsen
Feb 8, 2007·Current Opinion in Clinical Nutrition and Metabolic Care·Martine Armand
Nov 4, 2015·Food & Function·Laura SamsFrédéric Carrière
Aug 8, 1998·The American Journal of Physiology·M LedeboerC B Lamers
Jan 1, 1993·Archives Internationales De Physiologie, De Biochimie Et De Biophysique·J P PerretM Descroix-Vagne
Jan 13, 2005·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Peter Layer, Jutta Keller
Jan 13, 2005·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Frédéric CarrièreRené Laugier
Aug 8, 2006·Gastroenterology·Michael Camilleri
Mar 11, 2008·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Siddharth SinghPramod Kumar Garg

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