Gastric metastasis of hepatocellular carcinoma via a possible existing retrograde hematogenous pathway

Journal of Gastroenterology and Hepatology
Ming-Luen HuKing-Wah Chiu

Abstract

Hepatocellular carcinoma (HCC) tends to metastasize to extrahepatic organs. Stomach involvement has been seldom reported and has always been considered as direct invasion. This study aims to propose a possible existing pathway for the hematogenous metastasis of HCC to the stomach. Only seven cases with stomach involvement were found from 8267 HCC patients registered at our hospital between 2000 and 2007. Their laboratory data, the findings of computed tomography and upper endoscopy, therapeutic procedures, such as esophageal variceal banding ligation (EVL), and transhepatic arterial embolization (TAE) were further studied. All seven patients were male. Liver cirrhosis was found in six patients (6/7 = 85.7%), HCC with portal vein thrombosis (PVT) in six patients (6/7 = 85.7%), splenomegaly in five patients (5/7 = 71.4%) and esophageal varices in five patients (5/7 = 71.4%). Six patients underwent TAE and one patient underwent EVL before the development of HCC in the stomach. Four patients had HCC at the cardia, one patient at the anterior wall of the high body and two patients at the greater curvature of the high body, far away from the original HCC. Six patients eventually developed distant metastasis. HCC with gastric metastas...Continue Reading

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Citations

Aug 4, 2016·Clinical Journal of Gastroenterology·Koichiro HarukiKatsuhiko Yanaga
Jul 30, 2020·World Journal of Surgical Oncology·Yong-Ming YuZhong-Lei Shen
Jan 10, 2017·Journal of Gastrointestinal Cancer·Mohamed Seenikatty Abdul HakimSanjiv Mahadeva
Jan 2, 2021·Radiology Case Reports·Moheieldin M AbouziedMohammed H Al-Qahtani
Jun 7, 2021·Abdominal Radiology·Sandeep AroraAmir A Borhani

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