Gastric motor and sensory function in health assessed by magnetic resonance imaging: Establishment of reference intervals for the Nottingham test meal in healthy subjects

Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society
H L ParkerM R Fox

Abstract

Current investigations of gastric emptying rarely identify the cause of symptoms or provide a definitive diagnosis in patients with dyspepsia. This study assessed gastric function by magnetic resonance imaging (MRI) using the modular "Nottingham test meal" (NTM) in healthy volunteers (HVs). The NTM comprises (a) 400 mL liquid nutrient (0.75 kcal/mL) labeled with Gadolinium-DOTA and (b) an optional solid component (12 agar-beads [0 kcal]). Filling sensations were documented. MRI measurements of gastric volume, emptying, contraction wave frequency, and secretion were obtained using validated methods. Gastric function was measured in a population of 73 HVs stratified for age and sex. NTM induced moderate satiety and fullness. Labeled fluid was observed in the small bowel in all subjects after meal ingestion ("early-phase" GE). Secretion was rapid such that postprandial gastric content volume was often greater than meal volume (GCV0 > 400 mL), and there was increasing dilution of the meal during the study (P < 0.001). Gastric half-time was median 66-minutes (95% reference interval 35 to 161-minutes ["late-phase" GE]). The number of intact agar beads in the stomach was 7/12 (58%) at 60-minutes and 1/12 (8%) at 120-minutes. Age, body...Continue Reading

References

Apr 1, 1990·Gut·R H JonesJ M Bottomley
Jan 7, 1989·BMJ : British Medical Journal·R Jones, S Lydeard
Mar 1, 1995·Digestive Diseases and Sciences·N J TalleyA R Zinsmeister
Nov 26, 1999·Journal of Gastroenterology and Hepatology·K HirakawaY Kinoshita
Jul 14, 2000·The American Journal of Gastroenterology·G TougasR W McCallum
Apr 9, 2001·American Journal of Physiology. Gastrointestinal and Liver Physiology·L MarcianiR C Spiller
Aug 9, 2001·Annals of Medicine·R Rabin, F de Charro
Nov 7, 2001·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·L MarcianiR C Spiller
Jan 5, 2002·The British Journal of Clinical Psychology·J R CrawfordE P Taylor
May 10, 2003·The American Journal of Gastroenterology·Giovanni SarnelliJan Tack
Oct 16, 2003·European Journal of Gastroenterology & Hepatology·Ana GutiérrezJose Luis Olcoz
Apr 6, 2004·Journal of Magnetic Resonance Imaging : JMRI·Waleed AjajJoerg F Debatin
Aug 7, 2004·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·M FoxM Thumshirn
Oct 14, 2004·Gastroenterology·Jan TackGiovanni Sarnelli
Apr 6, 2006·JAMA : the Journal of the American Medical Association·Paul MoayyediNimish Vakil
Aug 8, 2006·American Journal of Physiology. Gastrointestinal and Liver Physiology·Ingrid M de ZwartAd A M Masclee
Oct 13, 2006·Journal of Magnetic Resonance Imaging : JMRI·Monika A KwiatekWerner Schwizer
Oct 25, 2006·Scandinavian Journal of Gastroenterology·Werner SchwizerMark Fox
Jun 27, 2007·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·H FruehaufM Fried
Nov 22, 2007·The American Journal of Gastroenterology·Thomas L AbellUNKNOWN American Neurogastroenterology and Motility Society and the Society of Nuclear Medicine
Apr 18, 2008·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·N J Talley
Apr 7, 2009·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·O GoetzeW Schwizer
Apr 17, 2009·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·H FruehaufO Goetze
May 6, 2009·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·M A KwiatekW Schwizer
Aug 12, 2009·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·S KindtJ Tack
Mar 23, 2010·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Richard A BrookNicholas J Talley
Mar 15, 2011·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Pankaj J PasrichaFrank Hamilton
Aug 24, 2011·Value in Health : the Journal of the International Society for Pharmacoeconomics and Outcomes Research·Guilherme Becker SanderUNKNOWN Helicobacter Eradication Relief of Dyspetic Symptoms Trial Investigators
Jun 1, 2012·The Journal of Nutrition·Luca MarcianiRobin C Spiller
May 1, 2013·The American Journal of Gastroenterology·Peter J KahrilasGuy Boeckxstaens
Sep 3, 2013·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·H VanheelJ Tack

❮ Previous
Next ❯

Citations

Aug 25, 2020·Gastroenterology Research and Practice·Yasutoshi ShiratoriKatsuyuki Fukuda
Feb 4, 2021·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·Nick GoelenPieter Janssen
Apr 3, 2021·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·Roberta ScloccoVitaly Napadow

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.