PMID: 8949638Sep 1, 1996Paper

Gastric mucosal contraction and vascular injury induced by indomethacin precede neutrophil infiltration in the rat

Gut
A AnthonyA J Wakefield

Abstract

In contrast with earlier reports that neutrophils play a primary part in non-steroidal anti-inflammatory drug (NSAID) injury to the stomach, recent evidence suggests only a secondary role for these cells. To examine whether early microscopic changes induced by indomethacin in the gastric corpus of fasted rats and the antrum of fasted-refed rats involve neutrophil infiltration. Oral indomethacin 30 mg/kg or vehicle was given to six groups of fasted rats that were killed five, 15, and 30 minutes after dosing. Subcutaneous indomethacin 30 mg/kg was also given to six groups of fasted-refed rats that were killed one, two, and four hours later. Haematoxylin and eosin and reticulin stained sections were examined to identify mucosal architectural changes. The gastric mucosa was also examined immunohistochemically for actin, fibrin, and neutrophils. In both the corpus and antrum, indomethacin caused an early phase of mucosal injury that occurred prior to mucosal neutrophil infiltration. Within the superficial corpus mucosa, this phase preceded coagulative necrosis and included surface epithelial expulsion, mucosal contraction with capillary aggregation and distortion, intravascular vascular fibrin deposition, and capillary congestion. T...Continue Reading

References

Jan 1, 1992·Scandinavian Journal of Gastroenterology. Supplement·J L Wallace
Dec 1, 1987·Archives of Internal Medicine·S H Roth, R E Bennett
Dec 1, 1995·Digestive Diseases and Sciences·R MelarangeJ Fuller

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Citations

Sep 1, 1999·Alimentary Pharmacology & Therapeutics·A Anthony
Jun 27, 2007·Journal of Gastroenterology and Hepatology·Mohammad TariqRamiz Al Swailam
Nov 5, 1997·The Journal of Pharmacy and Pharmacology·K WadaT Itoh
Aug 5, 2005·Naunyn-Schmiedeberg's Archives of Pharmacology·M FornaiM Del Tacca
Mar 14, 2007·Journal of Applied Toxicology : JAT·Nageswaran SivalingamMolly Jacob
Aug 2, 2014·The Journal of Surgical Research·Meltem KolgaziBerrak C Yeğen
Mar 15, 2003·The Journal of Pharmacy and Pharmacology·Yoshiro IshiwataToshikazu Yoshikawa

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