Gastric mucosal devitalization is safe and effective in reducing body weight and visceral adiposity in a porcine model

Gastrointestinal Endoscopy
Vivek KumbhariAndreas Oberbach

Abstract

The early improvement in metabolic profile after sleeve gastrectomy (SG) indicates that the significant benefits of metabolic surgery are gastric in origin. We have previously demonstrated that devitalization of the gastric mucosa (without a reduction in gastric volume) in metabolically disturbed obese rats results in an improvement of obesity and its associated comorbidities. The aims of this study were to assess the technical feasibility, efficacy, and safety of gastric mucosal devitalization (GMD) in a large animal (porcine) model. A 3-arm (GMD versus SG versus sham [SH]) prospective randomized controlled trial with an 8-week follow-up period was performed. The primary endpoint was relative weight loss. Secondary endpoints were absolute body weight, abdominal visceral adiposity, abdominal subcutaneous adiposity, organ lipid content, and serum ghrelin level. GMD resulted in a significant relative weight loss of 36% over SH at 8 weeks (P < .05). There was no significant difference in relative weight loss between GMD and SG at 4 weeks; however, SG resulted in a 29% superior relative weight loss at 8 weeks (P < .05). With regard to visceral adiposity, there was a significant benefit of GMD over SH at 8 weeks. Despite differences...Continue Reading

Citations

Sep 12, 2020·Journal of Digestive Diseases·Mohamad I ItaniVivek Kumbhari
Nov 19, 2020·Current Gastroenterology Reports·Jad FarhaDilhana Badurdeen
Jun 22, 2021·Gastrointestinal Endoscopy·Victoria GomezVivek Kumbhari
Aug 2, 2021·The Medical Journal of Australia·Dominic A StaudenmannAdrian Sartoretto

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