Gastric mucosal microbiota in a Mongolian population with gastric cancer and precursor conditions

Alimentary Pharmacology & Therapeutics
Boldbaatar GantuyaYoshio Yamaoka

Abstract

Incidence and mortality of gastric cancer (GC) are high in Mongolia despite Helicobacter pylori in the Mongolian population being less virulent. To evaluate gastric bacterial microbiota profiles in patients with GC and its precursor histological conditions. We conducted a case-control study among 48 GC and 120 noncancer patients (20 normal gastric mucosa [control], 20 gastritis, 40 with atrophy and 40 intestinal metaplasia [IM]). We performed 16S rRNA gene amplicon sequencing and compared taxonomic and functional prediction profiles based on the diagnosis group and H pylori infection status. The highest overall bacterial alpha diversity metrics were observed in the control group, followed by the IM and cancer groups. The gastritis and atrophy groups had the least diversity. Lactobacilli and Enterococci were the dominant genus in several cancer patients especially in the absence of H pylori. In addition, Carnobacterium, Glutamicibacter, Paeniglutamicibacter, Fusobacterium and Parvimonas were associated with GC regardless of H pylori infection. Firmicutes were decreased in the gastritis and atrophy groups and increased in the IM and cancer groups. The functional metabolic activity of the Embden-Meyerhof-Parnas pathway and the uti...Continue Reading

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Citations

May 24, 2020·Alimentary Pharmacology & Therapeutics·Cong HeNonghua Lu
May 24, 2020·Alimentary Pharmacology & Therapeutics·Boldbaatar GantuyaYoshio Yamaoka
Mar 16, 2021·Frontiers in Cellular and Infection Microbiology·Ting DongZhengwei Huang
Apr 2, 2021·Frontiers in Microbiology·Jinpu YangFeng Ji
May 4, 2021·Gut Microbes·Chieh-Chang ChenMing-Shiang Wu
May 13, 2021·Best Practice & Research. Clinical Gastroenterology·Joana Pereira-MarquesCeu Figueiredo
May 13, 2021·Best Practice & Research. Clinical Gastroenterology·Alexander LinkCosima Thon
Sep 11, 2021·Cellular and Molecular Gastroenterology and Hepatology·Annemieke SmetJan Bornschein
Oct 5, 2021·Frontiers in Cellular and Infection Microbiology·Tian LiangLongli Kang

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Atrophic Gastritis is a process where gastric glandular cells are lost and replaced with firbous tissues, as a result of chronic inflammation. Learn more about Atrophic Gastritis here.

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