PMID: 9544958Apr 17, 1998Paper

Gastric mucosal protection from enteral nutrients: role of motility

Journal of the American College of Surgeons
K S EphgraveK A Broadhurst

Abstract

Cold restraint stress increases the force of gastric contractions and produces gastric mucosal injury in rats. The aim of our study was to determine whether enteral glucose or hyperglycemia alone would alter the stress-induced gastric motility pattern and ameliorate the associated gastric mucosal injury. Adult male rats underwent surgical placement of gastric catheters, jugular venous catheters, and gastric strain gauge transducers 5 days before cold restraint. Three groups of rats received different substances during the same cold restraint stress protocol. Group 1 received 0.9% NaCl, 2 mL/h infused both intravenously (i.v.) and intragastrically (i.g.); group 2 received 0.9% NaCl, 2 mL/h i.g. plus 25% glucose, 2 mL/h i.v.; and group 3 received 0.9% NaCl, 2 mL/h i.v. plus 25% glucose i.g. Following baseline gastric motility measurements, all rats were restrained for 2 hours at 20 degrees C followed by 2 hours at 4 degrees C. Restraint even at room temperature increased the force of gastric contractions; the cold environment gradually prolonged gastric contractions. Enteral glucose blunted the effects of stress on gastric motility, increased gastric residual volume, decreased gastric acidity, and prevented gastric mucosal injury...Continue Reading

References

Aug 1, 1992·The Journal of Surgical Research·K S EphgraveL M Skaar
Dec 1, 1992·Digestive Diseases and Sciences·R L Kleiman-WexlerK A Broadhurst
Jun 1, 1990·Critical Care Medicine·K S EphgraveC G Adair
Jan 1, 1989·Scandinavian Journal of Gastroenterology. Supplement·H NishiwakiH Kohei
Jul 1, 1986·Critical Care Medicine·R J ValentineJ A Weigelt
Jul 1, 1988·Digestive Diseases and Sciences·N BassoA Materia
Jan 1, 1983·Critical Care Medicine·S K Pingleton, S K Hadzima
Mar 1, 1996·Digestive Diseases and Sciences·F Y ChangP S Wang

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Citations

Apr 17, 2003·The Journal of Surgical Research·Derek DuBayKimberly A Broadhurst
Jun 13, 2006·Seminars in Thoracic and Cardiovascular Surgery·Terrell A SingletonDennis C Gore
Jan 17, 2002·The Annals of Pharmacotherapy·R MacLarenD N Fish
Jul 19, 2002·Chest Surgery Clinics of North America·Katherine Trahan, Dennis C Gore
Jun 3, 2000·Gastroenterology Clinics of North America·U Beejay, M M Wolfe

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