Gastric secretion of acid and pepsin in patients with esophageal stricture and appropriate controls

Digestive Diseases and Sciences
B I Hirschowitz

Abstract

Most cases of esophageal stricture are associated with acid/peptic reflux esophagitis. While patients with strictures commonly have disordered lower esophageal sphincters and poor clearance and neutralization mechanisms, it is not known whether they also have abnormal gastric secretion. This study examined fasting, basal, and stimulated acid and pepsin secretion. With an endoscopic diagnosis of esophagitis, patients with stricture (< 12.5 mm) were matched for age, sex, concurrent gastrointestinal disease (duodenal ulcer, N = 9), Zollinger-Ellison syndrome (N = 6), and postgastric surgery state (N = 5), as well as the absence of ulcer disease (non-DU, N = 37). Fasting, basal, and pentagastrin-stimulated acid and pepsin secretion were measured. Overall, the 57 stricture patients had the same acid and pepsin secretion as their matched controls with esophagitis; the same was true for each of the subgroups (ZES, DU, non-DU, and postsurgical). Stricture patients weighed less and had a lower body mass index (P < 0.01). Patients with esophageal peptic stricture have the same acid and pepsin output as control patients matched for sex, age, background gastrointestinal disease, and the presence of esophagitis.

References

Jun 1, 1992·Scandinavian Journal of Gastroenterology·B I Hirschowitz
Dec 1, 1991·Journal of Clinical Gastroenterology·A Lanas, B I Hirschowitz
May 1, 1990·The American Journal of Medicine·G S McCord, R E Clouse
Jan 1, 1986·AJR. American Journal of Roentgenology·W J DoddsW J Hogan
Dec 1, 1987·Gastrointestinal Endoscopy·S A McClaveM R Gottfried
Feb 1, 1987·Gastroenterology·B J ZamostW M Weinstein
Jan 1, 1987·Gastrointestinal Radiology·Y M ChenH A Munitz
Aug 1, 1987·Annals of Surgery·L BonavinaR T Bailey
Oct 1, 1986·Gastroenterology·P J KahrilasA Reece
Jan 1, 1986·Scandinavian Journal of Gastroenterology·A BerstadM Hauer-Jensen
Feb 2, 1984·The New England Journal of Medicine·J F HelmB C Teeter
Sep 1, 1983·Digestive Diseases and Sciences·S J SpechlerE M Schimmel
Nov 30, 1995·The New England Journal of Medicine·J D Fine
Jan 1, 1995·Digestion·D Hopwood
Aug 1, 1995·Gastroenterology·R K MittalJ Dent
Jun 1, 1995·Alimentary Pharmacology & Therapeutics·C M Brown, W D Rees
Mar 1, 1995·The British Journal of Surgery·C P BarhamD Alderson
Apr 1, 1995·Journal of Clinical Gastroenterology·G A WeaverN B Merrell
Feb 1, 1995·Digestive Diseases and Sciences·B I HirschowitzG Sachs
Oct 1, 1993·Digestive Diseases and Sciences·B I Hirschowitz, J Groarke
Nov 1, 1995·European Journal of Gastroenterology & Hepatology·A I LanasR Sáinz

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Citations

Mar 1, 2000·Gastroenterology Clinics of North America·J E Richter
Mar 16, 2004·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Basil I HirschowitzJean Mohnen
Jul 14, 1999·Gut·H B El-SeragR M Feddersen
Aug 9, 2011·Gastroenterology Research and Practice·Andreas NakosKonstantinos Simopoulos
Mar 8, 2013·Case Reports in Gastroenterology·Emanuele SinagraMario Cottone
Jan 26, 2006·Expert Opinion on Pharmacotherapy·Jose M Nieto, Joseph R Pisegna
May 26, 2001·The American Journal of Gastroenterology·J D GardnerM Robinson
Mar 29, 2005·World Journal of Gastroenterology : WJG·Hajime IsomotoShigeru Kohno
Oct 1, 2004·Alimentary Pharmacology & Therapeutics·A Sonnenberg
Oct 16, 1999·The American Journal of Gastroenterology·L J WilsonB I Hirschowitz
Mar 27, 2003·Alimentary Pharmacology & Therapeutics·J D GardnerM Robinson
May 12, 2012·American Journal of Physiology. Gastrointestinal and Liver Physiology·Xin ChenHiroto Miwa
Oct 9, 2019·Best Practice & Research. Clinical Gastroenterology·Serhat Bor
Oct 12, 2001·Current Problems in Pediatric and Adolescent Health Care·B D Gold

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