Gastric siderosis: patterns and significance

The American Journal of Surgical Pathology
Esmeralda C MargineanDhanpat Jain

Abstract

Recently, we encountered 2 cases of diffuse iron deposition in gastric antral and fundic glandular epithelium, which in 1 patient eventually led to the diagnosis of hemochromatosis. Gastric mucosal siderosis (GS) has previously been described in hemochromatosis patients, alcoholics, and in association with iron medications. However, the prevalence of various patterns of iron deposition in the gastric mucosa and their clinical significance have not been studied in detail. The 2 index cases mentioned above and 500 additional consecutive gastric biopsies examined over a period of 8 months at our institution were stained for iron by the Prussian blue method. In addition, all patients with genetic hemochromatosis diagnosed by liver biopsy in our department between 1998 and 2003 who also had gastric biopsies were identified from the surgical pathology files and included in the study (n = 3). The location of iron deposition [stromal cells (endothelium, fibroblasts, macrophages), glandular epithelium, or extracellular] was recorded and subjectively graded as 1+ to 3+ according to the severity of deposition within the mucosa. Relevant histologic changes (inflammation, presence of H. pylori, ulceration) and clinical features were reviewe...Continue Reading

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Citations

Dec 8, 2009·Journal of Gastroenterology·Gregory Y LauwersMichio Shimizu
May 13, 2014·Seminars in Diagnostic Pathology·Nicole C Panarelli
Apr 7, 2007·The American Journal of Surgical Pathology·Lai Mun Wang, Michael McDermott
Jan 6, 2007·Histopathology·A Srivastava, G Y Lauwers
Dec 24, 2016·The American Journal of Surgical Pathology·Sophia M ShaddyChristina A Arnold
Mar 18, 2016·SAGE Open Medicine·Jiten P KothadiaShah Giashuddin
May 12, 2012·Virchows Archiv : an International Journal of Pathology·Xavier SagaertKarel Geboes
Jul 17, 2014·Journal of Clinical Pathology·Lysandra VoltaggioChristina A Arnold
Sep 12, 2013·International Journal of Surgical Pathology·Giovanni De PetrisDora Lam-Himlin
Nov 1, 2017·Porto Biomedical Journal·Rui MoraisGuilherme Macedo
Sep 27, 2018·Virchows Archiv : an International Journal of Pathology·Hala El-ZimaityRobert Riddell
Oct 16, 2019·Case Reports in Pediatrics·Daniel ChingDisna Abeysuriya
Feb 12, 2021·Archives of Pathology & Laboratory Medicine·Dipti M KaramchandaniChristina A Arnold

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