Gastric tone measured by an electronic barostat in health and postsurgical gastroparesis

F Azpiroz, J R Malagelada


Using a gastric barostat we have studied interdigestive variations in gastric tone and its response to gastric distention in 17 healthy volunteers and 5 patients with postsurgical gastroparesis. The barostat measures tone by monitoring the volume of air within a flaccid intragastric bag, maintained at a constant, preselected pressure level by an electronic feedback mechanism. In healthy individuals, inter-digestive variations in gastric tone were phase-locked in advance of duodenal interdigestive motor activity and consisted of three sequential periods; a quiescence period, an intermediate period, and a period of activity. In contrast to controls, gastroparetic patients presented significantly larger intragastric volume at low intragastric pressure (6 mmHg). Gastric distention (14 mmHg) resulted in significantly reduced extension ratio and phasic motor response in the gastric remnant. Furthermore, distention elicited a symptomatic response that resembled their postcibal syndrome (epigastric fullness, pain, nausea). These data suggest that postsurgical gastroparesis is associated with impaired tone of the residual gastric pouch.


Dec 1, 1991·Digestive Diseases and Sciences·H C van der MijleJ H Kleibeuker
Jan 1, 1990·Scandinavian Journal of Gastroenterology. Supplement·J R Malagelada
Jul 1, 1994·Digestive Diseases and Sciences·J ZighelboimS F Phillips
Apr 1, 1994·Digestive Diseases and Sciences·H C Van der MijleR van Schilfgaarde
Mar 1, 1996·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·T P TomaN J Talley
Apr 8, 1998·The American Journal of Physiology·P JouetB Flourié
Dec 9, 1998·Alimentary Pharmacology & Therapeutics·B MearadjiA A Masclee
Sep 28, 1999·Scandinavian Journal of Gastroenterology. Supplement·P J van der SchaarA A Masclee
Dec 22, 1999·The American Journal of Physiology·S D KuikenM K O'Connor
Apr 9, 2001·American Journal of Physiology. Gastrointestinal and Liver Physiology·B CoffinR Jian
Jul 27, 2001·The American Journal of Gastroenterology·B MearadjiA A Masclee
Nov 28, 2001·The American Journal of Gastroenterology·D Y KimD D Burton
Dec 4, 2001·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·T MoonK B Lee
Jun 14, 2002·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·Fernando Azpiroz
Feb 20, 2003·The American Journal of Gastroenterology·M Y A LindeboomA A M Masclee
Aug 30, 2003·American Journal of Physiology. Gastrointestinal and Liver Physiology·Hermann HarderJuan-R Malagelada
Sep 26, 2003·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·S M Scott
Oct 24, 2003·The American Journal of Gastroenterology·Magnus SimrénJan Tack
Mar 3, 2005·Journal of Gastroenterology and Hepatology·Guillaume SavoyePhilippe Ducrotté
Mar 4, 2005·Physics in Medicine and Biology·Donghua LiaoHans Gregersen
May 27, 2005·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·H Ouyang, J D Z Chen
May 28, 2005·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Patrick P J van der VeekAd A M Masclee
Jan 21, 2006·World Journal of Gastroenterology : WJG·Satish S C RaoKonrad S Schulze
Jul 20, 2006·Digestive Diseases·Hans GregersenDonghua Liao
May 25, 2007·The American Journal of Gastroenterology·Michele Di StefanoGino R Corazza
Jul 21, 2007·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·B HerrerosA Benages
Feb 20, 2010·Journal of Diabetes Science and Technology·Lawrence A Szarka, Michael Camilleri
Nov 10, 2009·European Journal of Gastroenterology & Hepatology·Patrick P J van der VeekAd A M Masclee
May 1, 2010·Gut and Liver·Tatsuhiro Masaoka, Jan Tack
Jun 1, 2011·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·D Ang
Sep 10, 2014·The American Journal of Gastroenterology·Michele Di StefanoGino Roberto Corazza
Jan 11, 2019·Nutrients·Hugo MonrroyFernando Azpiroz
Mar 1, 2012·Expert Review of Endocrinology & Metabolism·Anjali Amin, Kevin G Murphy
May 1, 1994·International Journal of Colorectal Disease·D García-OlmoJ Lopez-Fando
Mar 1, 1994·Digestive Diseases and Sciences·P ZacchiJ R Malagelada
Sep 1, 1995·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·G S HebbardJ Dent

❮ Previous
Next ❯

Related Concepts

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.


Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.


Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.