Gastrin and gastric enterochromaffin-like cell carcinoids in the rat

Digestion
E CarlssonL Ekman

Abstract

Life-long administration (greater than or equal to 2 years) of a number of long-acting gastric acid inhibitors (including H2-receptor antagonists, omeprazole and ciprofibrate) has been associated with the development of gastric enterochromaffin-like cell (ECL cell) carcinoids in rats. It has been postulated that they are a consequence of some unique property of the longer-acting acid inhibitors. There is, however, a great deal of evidence to support the hypothesis that these gastric ECL cell carcinoids develop as a result of life-long hypergastrinaemia in rats. Several lines of investigation reported here show that gastric ECL cell hyperplasia occurs when gastrin levels are increased without the use of acid-inhibiting drugs. In rats, hypergastrinaemia developed after 4 weeks' administration of exogenous gastrin (4 micrograms/kg/h). The number of gastric ECL cells per visual field had increased to 250 compared with 180 in the controls. Long-term hypergastrinaemia, induced by partial gastric corpectomy, increased plasma gastrin levels from 200 to 800 pg/ml and the density of gastric ECL cells increased from 190 to 310 cells/visual field 10 weeks after the operation. Importantly, gastric ECL cell hyperplasia, which was produced in...Continue Reading

Citations

Apr 1, 1991·Digestive Diseases and Sciences·S Holt, C W Howden
Feb 1, 1995·Gut·A A EkundayoR A Goodlad
Feb 22, 2001·Annual Review of Physiology·E Rozengurt, J H Walsh
Jul 6, 2005·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Reidar FossmarkHelge L Waldum
Jul 27, 2005·Alimentary Pharmacology & Therapeutics·A S RaghunathR C McLoughlin
Aug 1, 1994·Japanese Journal of Cancer Research : Gann·Y MatsushimaT Fujiwara

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