Gastrin and Helicobacter pylori in low-grade MALT lymphoma patients

Scandinavian Journal of Gastroenterology
S OhashiM Maeda

Abstract

This study of patients with Helicobacter pylori infection and low-grade MALT lymphoma aimed to investigate: 1) the effect of H. pylori eradication therapy on the serum gastrin level, 2) whether changes of the serum gastrin level after therapy could predict the prognosis of patients with this tumour, and 3) the relationship between the gastric H. pylori load, the serum gastrin level and the status of MALT lymphoma. Thirteen patients with documented low-grade MALT lymphoma and H. pylori infection were enrolled and received H. pylori eradication therapy as the sole initial treatment. The presence of H. pylori, the serum gastrin level, the endoscopic findings, the pathologic features of the biopsies and resected specimens, and the endoscopic ultrasonography findings were evaluated before and after therapy. Follow-up was carried out every 3-6 months. H. pylori eradication was eventually achieved in all 13 patients. The pretreatment fasting serum gastrin level decreased from 177.1 +/- 107.4 pg/ml to 129.2 +/- 78.1, 96.4 +/- 66.6 and 80.1 +/- 42.7 pg/ml after 0-3, 3-6 and 6-9 months, respectively (all P < 0.05). Successful eradication of H. pylori was followed by a decrease of the fasting serum gastrin level and complete regression of...Continue Reading

Citations

Dec 23, 2004·Journal of Virology·Elizabeth A Holley-GuthrieShannon C Kenney
Dec 31, 2008·World Journal of Gastroenterology : WJG·Michael D BurkittD Mark Pritchard
Jul 28, 2009·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Angelo ZulloDino Vaira
Feb 24, 2015·Gastroenterology Report·Sunil DachaMohammad Wehbi
Jun 18, 2009·The American Journal of Gastroenterology·Angelo ZulloDino Vaira
Jan 8, 2005·World Journal of Gastroenterology : WJG·Mei-Rong HeFa-Chao Zhi
Sep 12, 2009·Journal of Clinical Gastroenterology·Angelo ZulloSergio Morini
Oct 4, 2014·World Journal of Gastroenterology : WJG·Calogero VetroFrancesco Di Raimondo

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