PMID: 8994528Dec 1, 1996Paper

Gastrin levels in serum and bronchoalveolar lavage fluid of patients with lung cancer: comparison with patients with chronic obstructive pulmonary disease

Thorax
A DowlatiM Radermecker

Abstract

The gastrin gene is known to be expressed in all classes of bronchogenic carcinomas. Furthermore, high levels of gastrin have been reported in both the bronchoalveolar lavage (BAL) fluid and serum of patients with lung cancer. Based on these preliminary data a study was conducted to evaluate the usefulness of gastrin measurements in the diagnosis and staging of lung cancer. Thirty-five patients with lung cancer (26 non-small cell (NSCLC) and nine small cell (SCLC)) and 25 patients with chronic obstructive pulmonary disease underwent fibreoptic bronchoscopy and BAL. Gastrin levels were determined in both BAL fluid and the serum and compared with each other and with staging. No difference was found between the gastrin levels in the BAL fluid or serum of the study groups. There was no correlation with the stage in NSCLC and no correlation was found between the gastrin levels in the serum and the BAL fluid. A significant difference was seen in gastrin levels in BAL fluid between extensive and limited SCLC (p < 0.05). There is no evidence of clinical usefulness for gastrin measurements in lung cancer.

References

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Citations

Jun 10, 2006·Respiration; International Review of Thoracic Diseases·Anastasios RoussosKonstantinos I Gourgoulianis
Jul 16, 2011·Digestion·Maximilian V MalfertheinerPeter Malfertheiner
Mar 27, 2001·Gastroenterology·A Abou-SaifR T Jensen
Sep 6, 2005·Respiratory Medicine·Ferah EceFerda Aksoy
Jun 29, 2012·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Viboon BoonsarngsukChariya Laohavich
Apr 30, 2009·The Journal of Clinical Endocrinology and Metabolism·Sven GläserBeate Koch
Nov 11, 2008·American Journal of Respiratory and Critical Care Medicine·Johan Grunewald, Anders Eklund
Jan 1, 2003·World Journal of Gastroenterology : WJG·Anastasios RoussosKonstantinos I Gourgoulianis
Jan 20, 2004·Cancer Research·Theodore J KohTimothy C Wang

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