Gastrin Protects Against Myocardial Ischemia/Reperfusion Injury via Activation of RISK (Reperfusion Injury Salvage Kinase) and SAFE (Survivor Activating Factor Enhancement) Pathways

Journal of the American Heart Association
Xiaoli YangChunyu Zeng

Abstract

Ischemia/reperfusion injury (IRI) is one of the most predominant complications of ischemic heart disease. Gastrin has emerged as a regulator of cardiovascular function, playing a key protective role in hypoxia. Serum gastrin levels are increased in patients with myocardial infarction, but the pathophysiogical significance of this finding is unknown. The purpose of this study was to determine whether and how gastrin protects cardiac myocytes from IRI. Adult male Sprague-Dawley rats were used in the experiments. The hearts in living rats or isolated Langendorff-perfused rat hearts were subjected to ischemia followed by reperfusion to induce myocardial IRI. Gastrin, alone or with an antagonist, was administered before the induction of myocardial IRI. We found that gastrin improved myocardial function and reduced the expression of myocardial injury markers, infarct size, and cardiomyocyte apoptosis induced by IRI. Gastrin increased the phosphorylation levels of ERK1/2 (extracellular signal-regulated kinase 1/2), AKT (protein kinase B), and STAT3 (signal transducer and activator of transcription 3), indicating its ability to activate the RISK (reperfusion injury salvage kinase) and SAFE (survivor activating factor enhancement) pathw...Continue Reading

References

Mar 1, 1981·Acta Physiologica Scandinavica·V GerslK Uvnäs-Wallensten
Jun 4, 1993·European Journal of Pharmacology·L BojöJ Cassuto
Mar 14, 2001·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·E LindströmR Håkanson
Mar 7, 2003·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Cristina Sánchez-FernándezMaría S Fernández-Alfonso
Sep 8, 2004·Biochemical and Biophysical Research Communications·Saravanan RamamoorthyAndrea Todisco
Oct 14, 2004·Pflügers Archiv : European journal of physiology·Graham DockrayAndrea Varro
Jan 31, 2006·Molecular and Cellular Endocrinology·Ian L P Beales, O Ogunwobi
Mar 10, 2007·International Journal of Cardiology·Tsuyoshi IsonoToshiji Iwasaka
Jun 23, 2007·Current Topics in Medicinal Chemistry·Jens F RehfeldThomas V O Hansen
Dec 1, 2006·Nutrition Research Reviews·P GuilloteauR Zabielski
May 8, 2010·Cardiovascular Research·Michel OvizeUNKNOWN Working Group of Cellular Biology of Heart of European Society of Cardiology
Nov 3, 2010·Annals of the New York Academy of Sciences·Jeremy A Lavine, Alan D Attie
Jun 12, 2012·Clinical and Experimental Hypertension : CHE·Xiaoliang JiangZhiwei Yang
Jan 2, 2013·Frontiers in Bioscience (Elite Edition)·Amanda LochnerFrederic Nduhirabandi
Aug 3, 2013·Circulation Research·Richard S Vander Heide, Charles Steenbergen
Oct 22, 2013·Metabolism: Clinical and Experimental·Edgars LiepinshMaija Dambrova
Mar 26, 2014·The Journal of Physiology·Rod Dimaline, Andrea Varro
Sep 2, 2014·Kardiologiia·A S AmetovZ G Akhmedova
Sep 7, 2014·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Adam J Perricone, Richard S Vander Heide
Nov 15, 2014·American Journal of Physiology. Gastrointestinal and Liver Physiology·Marie LavalKathryn M Marshall
Feb 16, 2016·International Journal of Cardiology·Jens P GoetzeUrban Alehagen
Jan 31, 2017·Comprehensive Physiology·Theodore KalogerisRonald J Korthuis

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Citations

Mar 12, 2019·European Heart Journal. Acute Cardiovascular Care·Sebastian WibergFlemming Dela
Aug 23, 2019·Current Opinion in Gastroenterology·Mitchell L Schubert
Jul 14, 2020·Expert Opinion on Pharmacotherapy·Amit RoutPaul A Gurbel

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