Gastrin-releasing peptide (GRP, mammalian bombesin) in the pathogenesis of lung cancer

Progress in Growth Factor Research
J Viallet, J D Minna

Abstract

Established human lung cancer exhibits a complex pattern of genetic changes as well as several distinct autocrine growth factor loops for regulatory peptides. The best studied example is that of gastrin-releasing peptide (GRP), the mammalian homolog of the amphibian bombesin. It is produced by up to 70% of small cell lung cancers and 10-20% of non-small cell lung cancers. GRP stimulates the growth of normal bronchial epithelium as well as that of small cell lung cancer, and its blockade with the use of antibodies or synthetic antagonists inhibits the growth of these tumors. Study of its molecular biology has revealed a complex pattern of mRNA processing which has lead to the recent isolation of a novel family of peptides termed gastrin-releasing peptide gene-associated peptides (GGAPs), present in normal and malignant human tissues. Additional efforts have been directed at characterizing the GRP receptor as well as its intracellular signaling pathways which have been reported both as G protein phospholipase C coupled events as well as activation of a membrane associated tyrosine kinase. In view of its expression in normal bronchial epithelium and its mitogenic effects on this tissue, GRP appears to play a central role in the ea...Continue Reading

References

Jun 29, 1978·Nature·J WhartonA G Pearse
Sep 12, 1979·Biochemical and Biophysical Research Communications·T J McDonaldV Mutt
Dec 1, 1986·Molecular and Cellular Biology·D M CirilloP M Comoglio
Mar 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·P J Woll, E Rozengurt
Apr 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·G GaudinoP M Comoglio
Jan 1, 1988·Annals of the New York Academy of Sciences·E A SausvilleJ B Trepel
Mar 15, 1988·Cancer Research·R W AlexanderJ C Thompson
Jul 1, 1988·The Journal of Clinical Investigation·M VostrejsP A Seligman
Nov 15, 1988·Biochemical and Biophysical Research Communications·J B TrepelE A Sausville
Jan 1, 1985·The Journal of Clinical Investigation·S WeberT A Raffin
Oct 10, 1986·Science·E Rozengurt
Nov 1, 1986·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·A G PedersenH H Hansen
Jan 1, 1987·Somatic Cell and Molecular Genetics·A M Lebacq-VerheydenJ Battey
Dec 1, 1981·The Journal of Clinical Endocrinology and Metabolism·S M WoodS R Bloom
Sep 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·E R SpindelJ F Habener
Apr 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·M D ErismanL H Lazarus
Jul 1, 1982·Regulatory Peptides·G D SorensonO S Pettengill
May 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·E Rozengurt, J Sinnett-Smith

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Citations

Oct 1, 1996·Critical Reviews in Oncology/hematology·R de Castiglione, L Gozzini
Jun 4, 1999·Cancer Letters·W L Heusch, R Maneckjee
Mar 1, 1990·American Journal of Respiratory Cell and Molecular Biology·J Viallet, J D Minna
Jan 1, 1991·Critical Reviews in Oncology/hematology·J Viallet, D C Ihde
Jan 1, 1996·Journal of Cellular Biochemistry. Supplement·J Viallet, E A Sausville
Mar 21, 2017·Pharmacological Reports : PR·Saumitra Gajjar, Bhoomika M Patel
May 1, 2017·Pharmacological Reports : PR·Saumitra Gajjar, Bhoomika M Patel
Dec 10, 1991·Biochimica Et Biophysica Acta·D L Buchhagen

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