Gastrin-Releasing Peptide Is Involved in the Establishment of Allergic Rhinitis in Mice

The Laryngoscope
Yuma MatsumotoKoichiro Saito

Abstract

Gastrin-releasing peptide (GRP) is a neuropeptide that targets transmembrane-type receptors. Its role in allergic rhinitis (AR) has yet to be investigated. The present study utilized the nasal mucosa of AR model mice to examine GRP and GRP receptor (GRPR) expression levels, localization, and other factors to evaluate their role in AR pathology. In vivo study in an animal model. GRP and GRPR expression levels were examined in three different AR models established in BALB/c mice. In addition, a GRPR antagonist (RC-3095) was administered to AR mice to investigate its effect. The distribution of GRPR expression on mast cells in the nasal mucosa with AR was examined. Finally, we investigated the inhibitory effect of RC-3095 on allergy symptoms induced by histamine. GRP and GRPR were highly expressed in the nasal mucosal epithelium and interstitial tissues surrounding the nasal glands in AR groups according to immunostaining. GRP and GRPR expression as determined by western blotting increased in the nasal mucosa as the degree of nasal sensitization increased. In addition, the average counts of sneezing and nasal rubbing after treatment in the AR + RC-3095 group were significantly lower than those in the AR + nasal saline group. Mast ...Continue Reading

References

Apr 1, 1990·The Journal of Clinical Investigation·J N BaraniukM Kaliner
Aug 1, 1994·Clinical Otolaryngology and Allied Sciences·C J Woodhead
Jun 21, 1994·Proceedings of the National Academy of Sciences of the United States of America·T IshiiK Takeyasu
Jul 9, 2003·The Journal of Allergy and Clinical Immunology·Masao IwasakiYatsuji Ito
Jul 11, 2007·Current Opinion in Otolaryngology & Head and Neck Surgery·Dennis Kim, James N Baraniuk
Oct 20, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Kaoru TakamuraHiroshi Kiyono
Jun 12, 2009·Investigative Ophthalmology & Visual Science·David Valter PereiraFelipe Dal-Pizzol
Jan 22, 2011·Proceedings of the National Academy of Sciences of the United States of America·Shutang ZhouMary E Sunday
Jun 29, 2012·International Archives of Allergy and Immunology·Hui QiYing Wang
Apr 30, 2013·Inflammation & Allergy Drug Targets·Fabricia PetronilhoFelipe Dal-Pizzol

❮ Previous
Next ❯

Citations

Jan 5, 2021·Current Opinion in Endocrinology, Diabetes, and Obesity·Xiaoqun Qin, Xiangping Qu
Apr 22, 2021·The Journal of Immunology : Official Journal of the American Association of Immunologists·Chengxian XuKai Yang
Aug 21, 2021·Allergology International : Official Journal of the Japanese Society of Allergology·Michitsugu KawadaKoichiro Saito

❮ Previous
Next ❯

Related Concepts

Related Feeds

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.

Related Papers

Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]
Fabricia PetronilhoFelipe Dal-Pizzol
Investigative Ophthalmology & Visual Science
David Valter PereiraFelipe Dal-Pizzol
Histochemistry and Cell Biology
Lin LinKeqing Zhao
Inflammation & Allergy Drug Targets
Fabricia PetronilhoFelipe Dal-Pizzol
© 2022 Meta ULC. All rights reserved