Gastrin, somatostatin, G and D cells of gastric ulcer in rats

World Journal of Gastroenterology : WJG
Feng-Peng SunYong-Li Yao

Abstract

To investigate the relationship among gastrin, somatostatin, G and D cells in gastric ulcer and in its healing process in rats. Fourty-nine Wistar rats were divided into 7 groups. The gastric ulcer model was induced by acetic acid successfully. The gastrin and the somatostatin in rat plasma, gastric fluid and antral tissue were measured by radioimmunoassay(RIA). G and D cells in antral mucosa were analyzed with polyclonal antibody of gastrin and somatostatin by immunohistochemical method and Quantimet 500 image analysis system. In gastric ulcer, the level of gastrin in plasma, gastric fluid, and antral tissue increased, that of somatostatin declined, and the disorder gradually recovered to the normal level in the healing process. Immunohistochemical technique of G and D cells in antral mucosa demonstrated that the number of G cells increased and that of D cells decreased, both areas of G and D cells declined, the ratio of number and area of G/D increased in gastric ulcer, and the disorder gradually recovered in the healing process. In gastric ulcer, the increased gastrin secreted by G cells, the declined somatostatin secreted by D cells, and the disordered G/D cell ratio can lead to gastrointestinal dysfunction.

References

Apr 1, 1997·Histopathology·C PesceR Tanzi
Apr 1, 1997·European Journal of Gastroenterology & Hepatology·P ChamouardR Baumann
Jun 1, 1997·The American Journal of Physiology·K C LloydJ H Walsh
Aug 1, 1997·The American Journal of Physiology·J M RayA M Buchan
May 12, 1998·The American Journal of Physiology·Y ZavrosA Shulkes
Jul 31, 1998·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·N A Wright
Sep 3, 1998·Alimentary Pharmacology & Therapeutics·B AnnibaleG Delle Fave
Jan 14, 1999·The American Journal of Physiology·Y ZavrosA Shulkes
Jan 14, 1999·The American Journal of Physiology·P E SquiresA M Buchan
Jul 18, 2000·American Journal of Physiology. Gastrointestinal and Liver Physiology·J MorissetJ Bourassa
Oct 18, 2000·Regulatory Peptides·E SolciaC Capella
Mar 21, 2001·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·M Tzaneva
Apr 4, 2001·Digestive Diseases and Sciences·I L Beales
Jun 16, 2001·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·A C BergerH R Alexander
Jul 5, 2001·Biochemical and Biophysical Research Communications·S Kermorgant, T Lehy
Jul 18, 2001·Biological & Pharmaceutical Bulletin·T NaitoM Takeyama
Aug 2, 2001·Digestive Diseases and Sciences·M CaplinA Dhillon
Aug 24, 2001·American Journal of Physiology. Gastrointestinal and Liver Physiology·S HiraokaY Matsuzawa
Sep 5, 2001·The Journal of Peptide Research : Official Journal of the American Peptide Society·A JaneckaT Janecki
Jan 31, 2002·World Journal of Gastroenterology : WJG·Yu-Qiang ChenYan-Xu Chen
Jan 31, 2002·World Journal of Gastroenterology : WJG·Bi-Guang TuoKui Zhao
Jan 31, 2002·World Journal of Gastroenterology : WJG·Y L YaoY G Song
Jan 31, 2002·World Journal of Gastroenterology : WJG·Y L LingX P Zhang
Feb 21, 2002·World Journal of Gastroenterology : WJG·X PengS L Wang

❮ Previous
Next ❯

Citations

Mar 31, 2004·World Journal of Gastroenterology : WJG·Xiao-Chang XueYing-Qi Zhang
Sep 13, 2003·World Journal of Gastroenterology : WJG·Chun-Hui WangLi-Ping Tang
Jul 31, 2018·Journal of Applied Animal Welfare Science : JAAWS·Leonardo Ramón LeggieriPablo Carmanchahi
Mar 31, 2004·World Journal of Gastroenterology : WJG·Qin PanQin-Fang Xu
Dec 12, 2003·World Journal of Gastroenterology : WJG·Feng-Peng Sun, Yu-Gang Song
Aug 5, 2005·Biological & Pharmaceutical Bulletin·Susumu Okabe, Kikuko Amagase
Nov 28, 2018·Journal of the Science of Food and Agriculture·Xingyao LongHuayi Suo
Mar 26, 2013·Molecular Medicine Reports·Jingjing WangBo Han
Oct 30, 2015·BMC Complementary and Alternative Medicine·Leônia Maria BatistaAlba Regina Monteiro Souza Brito
Oct 29, 2005·Journal of Ethnopharmacology·Clélia Akiko Hiruma-LimaAlba Regina Monteiro Souza Brito
Nov 22, 2008·Journal of Ethnopharmacology·Clélia Akiko Hiruma-LimaAlba Regina Monteiro Souza Brito

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

World Journal of Gastroenterology : WJG
Feng-Peng Sun, Yu-Gang Song
Di 1 jun yi da xue xue bao = Academic journal of the first medical college of PLA
Feng-Peng SunWei Cheng
Scandinavian Journal of Gastroenterology. Supplement
E SchrumpfJ Myren
© 2022 Meta ULC. All rights reserved