PMID: 6537937Jan 1, 1984Paper

Gastro-intestinal absorption and in vitro release of boric acid from water-emulsifying ointments

Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association
J A JansenB Aggerbeck

Abstract

Boric acid taken orally by six male volunteers in a cross-over study was absorbed to equal extents from a water solution and a 3% waterless, water-emulsifying ointment, though with a slight initial delay in the latter case. Virtually complete gastro-intestinal absorption and renal excretion were indicated by the 96-hr urinary recovery, amounting to 89.1-98.3% (mean 93.9%) and 89.2-97.5% (mean 92.4%) of the dose ingested as solution and ointment, respectively, normal daily boron excretion having been taken into account. The in vitro release of boric acid, measured for 24 hr by dialysis in water at 37 degrees C, reached 95% from a purely water-based jelly but only about 5% from the water-emulsifying ointment. The low boric acid release from the ointment was not significantly influenced when the ointment was dialysed against buffer solutions of pH 2.5 and 9.6 instead of water, or when the maximum possible amount of water (26.9% w/w) was incorporated into the ointment before dialysis. The 24-hr boric acid release from a number of other oil-based ointments, either hydrophobic or water-emulsifying and containing 1-3% boric acid and 0-28.5% water, was also low (0.9-18.3% of the boric acid content). This indicates that the formulation ...Continue Reading

References

Feb 1, 1971·Analytical Chemistry·A KaczmarczykC E Peirce
Aug 1, 1982·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·B Friis-HansenJ A Jansen
Jan 1, 1982·Archives of Dermatological Research·G StüttgenB Aggerbeck
Jun 6, 1963·The New England Journal of Medicine·F P BORNSTEIN
Jun 10, 1933·British Medical Journal·J E Lloyd

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Citations

Mar 1, 1984·Archives of Toxicology·J A JansenJ S Schou
Mar 2, 1999·Biological Trace Element Research·B SutherlandJ C King
Mar 2, 1999·Biological Trace Element Research·F J Murray
Mar 2, 1999·Biological Trace Element Research·C J PriceM M Goldberg
Jul 22, 2009·European Journal of Emergency Medicine : Official Journal of the European Society for Emergency Medicine·Francesco CorradiGiulio Belvederi
Dec 8, 2009·Reproductive Toxicology·Wendie A RobbinsLiu Ping
Oct 1, 1991·Toxicology and Applied Pharmacology·W W KuK Y Adams
Oct 4, 2005·Journal of Renal Nutrition : the Official Journal of the Council on Renal Nutrition of the National Kidney Foundation·Madeleine V PahlNosratola D Vaziri
Jan 27, 1998·Regulatory Toxicology and Pharmacology : RTP·A G CraanD W Green
Jan 25, 2021·Regulatory Toxicology and Pharmacology : RTP·Niels HadrupAnoop K Sharma
May 1, 2020·Journal of Pharmaceutical Sciences·Antonio LopalcoValentino J Stella

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